Lindén C J, Johansson L
Department of Lung Medicine, University Hospital, Lund, Sweden.
In Vivo. 1988 Sep-Oct;2(5):345-8.
We xenografted cells from eight human pleural mesotheliomas to athymic rats and from one tumour to athymic mice. Four of the tumours grew for one or more passages in rats. Two of the tumours could be serially long-term passaged in athymic animals over a period of 33 months for 27 passages and 41 months for 18 passages, respectively. The growth rates of the two long-term transplantable tumours increased during the initial passages, after which the tumour-volume doubling time remained 3-5 days. Only one of the nine transplanted mesotheliomas exhibited growth characteristics suitable for drug-testing experiments.
我们将来自8例人类胸膜间皮瘤的细胞移植到无胸腺大鼠体内，并将1例肿瘤的细胞移植到无胸腺小鼠体内。其中4例肿瘤在大鼠体内传代1次或多次。其中2例肿瘤能够在无胸腺动物中连续长期传代，分别传代27次历时33个月，以及传代18次历时41个月。这2例可长期移植的肿瘤在最初传代期间生长速率增加，之后肿瘤体积倍增时间保持在3 - 5天。9例移植的间皮瘤中只有1例表现出适合药物测试实验的生长特性。
