Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, Novi Sad, Serbia.
Nanotechnology. 2018 Aug 17;29(33):332002. doi: 10.1088/1361-6528/aac7dd. Epub 2018 May 25.
Nanotechnology, focused on discovery and development of new pharmaceutical products is known as nanopharmacology, and one research area this branch is engaged in are nanopharmaceuticals. The importance of being nano has been particularly emphasized in scientific areas dealing with nanomedicine and nanopharmaceuticals. Nanopharmaceuticals, their routes of administration, obstacles and solutions concerning their improved application and enhanced efficacy have been briefly yet comprehensively described. Cancer is one of the leading causes of death worldwide and evergrowing number of scientific research on the topic only confirms that the needs have not been completed yet and that there is a wide platform for improvement. This is undoubtedly true for nanoformulations of an anticancer drug doxorubicin, where various nanocarrriers were given an important role to reduce the drug toxicity, while the efficacy of the drug was supposed to be retained or preferably enhanced. Therefore, we present an interdisciplinary comprehensive overview of interdisciplinary nature on nanopharmaceuticals based on doxorubicin and its nanoformulations with valuable information concerning trends, obstacles and prospective of nanopharmaceuticals development, mode of activity of sole drug doxorubicin and its nanoformulations based on different nanocarriers, their brief descriptions of biological activity through assessing in vitro and in vivo behavior.
纳米技术专注于新药的发现和开发，被称为纳米药理学，该分支的一个研究领域是纳米药物。在涉及纳米医学和纳米药物的科学领域中，纳米的重要性尤其被强调。本文简要而全面地描述了纳米药物、它们的给药途径、改善其应用和提高疗效所面临的障碍和解决方案。癌症是全球主要的死亡原因之一，越来越多的科学研究证实，这方面的需求尚未得到满足，还有很大的改进空间。这对于阿霉素等抗癌药物的纳米制剂来说无疑是正确的，其中各种纳米载体被赋予了降低药物毒性的重要作用，而药物的疗效应该得到保留或更好地增强。因此，我们基于阿霉素及其纳米制剂，呈现了一篇跨学科的纳米药物综述，其中包含了有关纳米药物发展的趋势、障碍和前景、单一药物阿霉素及其基于不同纳米载体的纳米制剂的作用模式、通过评估体外和体内行为来描述其生物学活性等有价值的信息。
