Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Mental Health Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
BMC Psychiatry. 2018 May 25;18(1):149. doi: 10.1186/s12888-018-1717-8.
Accumulating evidences indicated that mitochondrial abnormalities were associated with bipolar disorder. As a sensitive index of mitochondrial function and biogenesis, Mitochondrial DNA copy number (mtDNAcn) may be involved in the pathophysiology of bipolar disorder.
Leukocyte relative mtDNAcn was measured by quantitative polymerase chain reaction in subjects with BD (n = 131) in manic, depressive, and euthymic symptoms. Thirty-four healthy individuals were used as comparison control. BD clinical symptomatology was evaluated by Young Mania Rating Scale (YMRS), Hamilton Depression Scale (HAM-D), Clinical Global Impression-Bipolar Disorder-Severity of Illness Scale (CGI-BD-S), and the Positive and Negative Syndrome Scale (PANSS).
Compared to healthy controls, BD patients with manic and depressive symptoms presented significantly decreased mtDNAcn levels (p-value = 0.009 and 0.041, respectively). No significant differences were detected in mtDNAcn between euthymic patients and healthy controls. The mtDNAcn was negatively correlated with the number of relapses in manic patients (β = - 0.341, p = 0.044).
Our study described the first evidence of (1) a significant decline of mtDNAcn in manic BD patients, (2) a similar decreased level of mtDNAcn between manic and depressed BD patients, (3) a negative correlation of mtDNAcn with number of relapses in patients suffering from manic states. Alterations of mtDNAcn in manic and depressed patients, which may reflect disturbances of energy metabolism, supported the role of mitochondrial abnormalities in the pathophysiology of BD.
越来越多的证据表明线粒体异常与双相情感障碍有关。线粒体 DNA 拷贝数（mtDNAcn）作为线粒体功能和生物发生的敏感指标，可能参与双相情感障碍的病理生理学过程。
通过定量聚合酶链反应测量有躁狂、抑郁和缓解症状的双相情感障碍患者（n=131）白细胞相对 mtDNAcn。34 名健康个体作为对照。使用 Young Mania Rating Scale（YMRS）、Hamilton Depression Scale（HAM-D）、Clinical Global Impression-Bipolar Disorder-Severity of Illness Scale（CGI-BD-S）和 Positive and Negative Syndrome Scale（PANSS）评估双相情感障碍的临床症状。
与健康对照组相比，有躁狂和抑郁症状的双相情感障碍患者的 mtDNAcn 水平显著降低（p 值分别为 0.009 和 0.041）。缓解期患者的 mtDNAcn 与健康对照组之间无显著差异。mtDNAcn 与躁狂患者的复发次数呈负相关（β= -0.341，p=0.044）。
本研究首次描述了（1）躁狂双相情感障碍患者 mtDNAcn 显著下降，（2）躁狂和抑郁双相情感障碍患者 mtDNAcn 水平相似，（3）躁狂状态患者 mtDNAcn 与复发次数呈负相关。躁狂和抑郁患者 mtDNAcn 的改变，可能反映了能量代谢的紊乱，支持了线粒体异常在双相情感障碍病理生理学中的作用。
