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本文引用的文献

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Neonatal brain injuries in England: population-based incidence derived from routinely recorded clinical data held in the National Neonatal Research Database.英格兰新生儿脑损伤:基于人群的发病率,源自国家新生儿研究数据库中常规记录的临床数据。
Arch Dis Child Fetal Neonatal Ed. 2018 Jul;103(4):F301-F306. doi: 10.1136/archdischild-2017-313707. Epub 2017 Oct 22.
2
Term admissions to neonatal units in England: a role for transitional care? A retrospective cohort study.英格兰新生儿病房的足月分娩入院病例:过渡性护理是否能发挥作用?一项回顾性队列研究。
BMJ Open. 2017 May 29;7(5):e016050. doi: 10.1136/bmjopen-2017-016050.
3
A Clinical Prediction Rule for Rebound Hyperbilirubinemia Following Inpatient Phototherapy.住院光疗后反弹高胆红素血症的临床预测规则
Pediatrics. 2017 Mar;139(3). doi: 10.1542/peds.2016-2896. Epub 2017 Feb 14.
4
Neonatal jaundice: summary of NICE guidance.新生儿黄疸:英国国家卫生与临床优化研究所(NICE)指南总结
BMJ. 2010 May 19;340:c2409. doi: 10.1136/bmj.c2409.
5
Impact of universal bilirubin screening on severe hyperbilirubinemia and phototherapy use.普遍胆红素筛查对严重高胆红素血症及光疗使用的影响。
Pediatrics. 2009 Oct;124(4):1031-9. doi: 10.1542/peds.2008-2980. Epub 2009 Sep 28.
6
A proposal to prevent severe neonatal hyperbilirubinemia and kernicterus.预防重度新生儿高胆红素血症和核黄疸的一项提议。
J Perinatol. 2009 Feb;29 Suppl 1:S61-7. doi: 10.1038/jp.2008.213.
7
Prospective surveillance study of severe hyperbilirubinaemia in the newborn in the UK and Ireland.英国和爱尔兰新生儿严重高胆红素血症的前瞻性监测研究。
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从理赔中学习:高胆红素血症和核黄疸。

Learning from claims: hyperbilirubinaemia and kernicterus.

机构信息

Neonatal Unit, University College Hospital, London, UK.

Obstetrics, NHS Resolution, London, UK.

出版信息

Arch Dis Child Fetal Neonatal Ed. 2019 Mar;104(2):F202-F204. doi: 10.1136/archdischild-2017-314622. Epub 2018 May 25.

DOI:10.1136/archdischild-2017-314622
PMID:29802103
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6580733/
Abstract

We examined claims made against the National Health Service (NHS) involving neonatal jaundice in order to determine whether there were lessons that could be learnt from common themes.This was a retrospective anonymised study using information from the NHS Resolution database for 2001-2011.Twenty cases (16 males) had sufficient information for analysis. Fifteen had confirmed cerebral palsy and two young children had damage to the globus pallidus without confirmed CP. In three cases, the outcome was uncertain. Two were extremely preterm, five were born at 34-36 weeks' gestation. Jaundice was typically present very early in life; in four cases, it was noted at less than 24hours of age, and in 14 cases, it was first noted on the second to third day. There was a lag between recognition and readmission, with a range of 26-102 hours. The peak serum bilirubin level was over 600 µmol/L in all the babies born at term. An underlying diagnosis was found in all but two; six had glucose-6-phosphatase deficiency (one also had Gilbert's syndrome); five were diagnosed with ABO incompatibility; three with Rh haemolytic disease; one with spherocytosis and three preterm. The total cost of these claims by August 2017 was almost £150.5 million. This figure is likely to rise.These data show that, in the group who litigate, babies who develop kernicterus generally have an underlying diagnosis. We recommend adherence to theNational Institute for Health and Care Excellence guideline that recommends measuring the bilirubin level within 6 hours in all babies who are visibly jaundiced.

摘要

我们研究了针对国民保健制度(NHS)涉及新生儿黄疸的索赔,以确定是否可以从常见主题中吸取教训。这是一项回顾性匿名研究,使用了 NHS Resolution 数据库 2001-2011 年的数据。有足够信息进行分析的案例有 20 例(男性 16 例)。其中 15 例确诊为脑瘫,2 例幼儿苍白球损伤,未确诊脑瘫。在三种情况下,结果不确定。其中两例为极早产儿,五例出生于 34-36 周。黄疸通常在生命早期出现;在 4 例中,在出生后不到 24 小时就出现了,在 14 例中,在第 2-3 天首次出现。从识别到重新入院之间存在延迟,时间范围为 26-102 小时。所有足月出生的婴儿的血清胆红素峰值均超过 600µmol/L。除了两例外,所有婴儿都发现了潜在的诊断;6 例患有葡萄糖-6-磷酸脱氢酶缺乏症(1 例还患有 Gilbert 综合征);5 例诊断为 ABO 不相容性;3 例为 Rh 溶血病;1 例为球形红细胞增多症,3 例为早产儿。截至 2017 年 8 月,这些索赔的总费用几乎为 1.505 亿英镑。这一数字可能会上升。这些数据表明,在起诉的婴儿中,患有核黄疸的婴儿通常有潜在的诊断。我们建议遵循国家卫生与保健卓越研究所的指南,即建议对所有明显黄疸的婴儿在 6 小时内测量胆红素水平。