Sattarifard Hedieh, Hashemi Mohammad, Hassanzarei Shekoofeh, Narouie Behzad, Bahari Gholamreza
Cellular and Molecular Research Center, School of Medicine, Zahedan University of Medical Sciences, Zahedan 98167-43181, Iran.
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan 98167-43181, Iran.
Mol Clin Oncol. 2017 Dec;7(6):1152-1158. doi: 10.3892/mco.2017.1462. Epub 2017 Oct 18.
The aim of the present study was to determine whether there is an association between the long non-coding RNA (lncRNA) prostate cancer-associated non-coding RNA 1 () polymorphisms and prostate cancer (PCa) risk in a sample of the Iranian population. This case-control study was performed on 178 patients with PCa and 180 subjects with benign prostatic hyperplasia (BPH). Genotyping assay was performed by polymerase chain reaction-restriction fragment length polymorphism. The findings indicated that the GG genotype of the rs13252298 A>G variant significantly increased the risk of PCa (odds ratio=3.49, 95% confidence interval: 1.79-6.81, P=0.0001) compared with AA+AG. As regards the rs1456315 G>A polymorphism, the AG genotype and G allele significantly increased the risk of PCa. As regards the rs7841060 T>G variant, the findings demonstrated that this TG genotype and the G allele significantly increased the risk of PCa. The rs7007694 T>C variant was not found to be associated with the risk of PCa. Haplotype analysis indicated that GTGA and GTGG significantly increased the risk of PCa compared with rs1456315A/rs7007694T/rs7841060T/rs13252298G (ATTG). The variants were not found to be significantly associated with the clinicopathological characteristics of PCa patients. In conclusion, our findings support an association between variants and the risk of PCa in a sample of the Iranian population.
本研究的目的是确定在伊朗人群样本中，长链非编码RNA（lncRNA）前列腺癌相关非编码RNA 1（）多态性与前列腺癌（PCa）风险之间是否存在关联。这项病例对照研究对178例PCa患者和180例良性前列腺增生（BPH）患者进行。采用聚合酶链反应-限制性片段长度多态性进行基因分型检测。研究结果表明，与AA + AG相比，rs13252298 A>G变异的GG基因型显著增加了PCa风险（优势比=3.49，95%置信区间：1.79 - 6.81，P = 0.0001）。关于rs1456315 G>A多态性，AG基因型和G等位基因显著增加了PCa风险。关于rs7841060 T>G变异，研究结果表明该TG基因型和G等位基因显著增加了PCa风险。未发现rs7007694 T>C变异与PCa风险相关。单倍型分析表明，与rs1456315A/rs7007694T/rs7841060T/rs13252298G（ATTG）相比，GTGA和GTGG显著增加了PCa风险。未发现这些变异与PCa患者的临床病理特征显著相关。总之，我们的研究结果支持在伊朗人群样本中，这些变异与PCa风险之间存在关联。
