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[危重症患者的胃肠动力]

[Gastrointestinal motility in critically ill patients].

作者信息

Madl C, Madl U

机构信息

4. Medizinische Abteilung mit Gastroenterologie und Hepatologie, Krankenanstalt Rudolfstiftung, Juchgasse 25, 1030, Wien, Österreich.

Medizinische Fakultät, Sigmund Freud PrivatUniversität, Wien, Österreich.

出版信息

Med Klin Intensivmed Notfmed. 2018 Jun;113(5):433-442. doi: 10.1007/s00063-018-0446-6. Epub 2018 May 25.

DOI:10.1007/s00063-018-0446-6
PMID:29802424
Abstract

Up to 80% of all critically ill patients develop gastrointestinal dysfunction, predominantly gastrointestinal motility disorder. In critically ill patients, gastrointestinal dysfunction or gastrointestinal failure is associated with increased morbidity and mortality. Correct diagnosis and early start of treatment are essential and can influence the outcome. Therapeutic options are normal potassium and magnesium levels, restrictive fluid balance, improved gastrointestinal microcirculation, individual sedoanalgetic concepts and early enteral nutrition. In addition, numerous target-oriented medical therapeutic options are available.

摘要

高达80%的重症患者会出现胃肠功能障碍,主要是胃肠动力紊乱。在重症患者中,胃肠功能障碍或胃肠衰竭与发病率和死亡率增加相关。正确诊断并尽早开始治疗至关重要,且会影响治疗结果。治疗选择包括正常的钾和镁水平、限制性液体平衡、改善胃肠微循环、个体化的镇静镇痛方案以及早期肠内营养。此外,还有许多靶向性的医学治疗选择。

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本文引用的文献

1
Severity of acute gastrointestinal injury grade is a predictor of all-cause mortality in critically ill patients: a multicenter, prospective, observational study.严重程度急性胃肠损伤分级是危重症患者全因死亡率的预测因子:一项多中心、前瞻性、观察性研究。
Crit Care. 2017 Jul 14;21(1):188. doi: 10.1186/s13054-017-1780-4.
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[Nutrition and gastrointestinal intolerance].[营养与胃肠道不耐受]
Med Klin Intensivmed Notfmed. 2013 Jun;108(5):396-400. doi: 10.1007/s00063-012-0203-1. Epub 2013 Jun 7.
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Gut-origin sepsis: evolution of a concept.
基于网络药理学分析,胃舒汤中的关键成分芹菜素可缓解胃肠动力障碍。
Mediators Inflamm. 2021 Sep 21;2021:5265444. doi: 10.1155/2021/5265444. eCollection 2021.
肠道来源的脓毒症:概念的演变。
Surgeon. 2012 Dec;10(6):350-6. doi: 10.1016/j.surge.2012.03.003. Epub 2012 Apr 23.
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[S3 guideline of the German Society for Digestive and Metabolic Diseases (DGVS) and the German Society for Neurogastroenterology and Motility (DGNM) to the definition, pathophysiology, diagnosis and treatment of intestinal motility].[德国消化和代谢疾病学会(DGVS)及德国神经胃肠病学和动力学会(DGNM)关于肠道动力的定义、病理生理学、诊断和治疗的S3指南]
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[Disturbances of gastrointestinal motility in intensive care units].[重症监护病房中的胃肠动力障碍]
Anasthesiol Intensivmed Notfallmed Schmerzther. 2010 Nov;45(11-12):696-706. doi: 10.1055/s-0030-1268871. Epub 2010 Nov 30.
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Bench-to-bedside review: the gut as an endocrine organ in the critically ill.床旁综述:危重病患者的肠道作为内分泌器官。
Crit Care. 2010;14(5):228. doi: 10.1186/cc9039. Epub 2010 Sep 24.
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Gastrointestinal symptoms in intensive care patients.重症监护患者的胃肠道症状
Acta Anaesthesiol Scand. 2009 Mar;53(3):318-24. doi: 10.1111/j.1399-6576.2008.01860.x.
8
Gastrointestinal failure score in critically ill patients: a prospective observational study.危重症患者的胃肠功能衰竭评分:一项前瞻性观察研究。
Crit Care. 2008;12(4):R90. doi: 10.1186/cc6958. Epub 2008 Jul 14.
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Gastrointestinal motility in acute illness.急性疾病中的胃肠动力
Wien Klin Wochenschr. 2008;120(1-2):6-17. doi: 10.1007/s00508-007-0920-2.
10
Effects of propofol and fentanyl on duodenal motility activity in pigs.丙泊酚和芬太尼对猪十二指肠运动活性的影响。
Can Vet J. 2005 Nov;46(11):995-1001.