Institute for Community Medicine, University Medicine Greifswald, Walther Rathenau Str. 48, 17475, Greifswald, Germany.
Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Greifswald, Germany.
Eur J Nutr. 2019 Aug;58(5):1815-1820. doi: 10.1007/s00394-018-1731-0. Epub 2018 May 25.
Data from recent adult studies suggest a decline of median urinary iodine concentrations (UIC) in Germany, but since 1996 no German study investigated UIC in neonates. The aim of our study was to investigate UIC and serum thyroid-stimulating hormone (TSH) levels in neonates from Germany.
We used data from 399 neonates, which were born between April 2005 and November 2006 in the Northeast of Germany. UIC were evaluated by a photometric procedure with Sandell and Kolthoff reaction and afterwards corrected to be comparable with an ICP-MS method. TSH was determined from capillary blood, which was taken within 5 days after birth, by DELFIA.
Median UIC were 150 µg/L (25th percentile: 104 µg/L; 75th percentile: 196 µg/L) and differed between boys (153.3 µg/L) and girls (131.5 µg/L; p = 0.012). The prevalence of serum TSH levels > 5 mIU/L was 14%. Neonates from mothers with intake of iodine supplementation (150 µg/L) had significantly higher median UIC than neonates from mothers without iodine supplementation (132 µg/L; p = 0.011). Multivariable linear regression adjusted for sex and iodine supplementation of the mother revealed a significant association between UIC and log-transformed serum TSH levels (β = 0.003: 95% confidence interval (CI) = 0.0001-0.005; p = 0.028).
Neonates in Northeast Germany did show a sufficient supply of iodine. This points towards the possibility of a sufficient iodine supply of neonates also in other regions of Germany, even though recent studies in adults may indicate mild iodine deficiency.
最近的成人研究数据表明，德国的中位尿碘浓度（UIC）呈下降趋势，但自 1996 年以来，德国没有研究调查过新生儿的 UIC。本研究旨在调查德国新生儿的 UIC 和血清促甲状腺激素（TSH）水平。
我们使用了 2005 年 4 月至 2006 年 11 月期间在德国东北部出生的 399 名新生儿的数据。UIC 通过光度法测定，采用桑德尔和科尔托夫反应，然后校正为与电感耦合等离子体质谱法（ICP-MS）可比。TSH 是从出生后 5 天内采集的毛细血管血中通过 DELFIA 测定的。
中位 UIC 为 150μg/L（25 百分位数：104μg/L；75 百分位数：196μg/L），男孩（153.3μg/L）与女孩（131.5μg/L）之间存在差异（p=0.012）。血清 TSH 水平>5mIU/L 的患病率为 14%。接受碘补充剂（150μg/L）的母亲的新生儿的 UIC 中位数显著高于未接受碘补充剂的母亲的新生儿（132μg/L；p=0.011）。经性别和母亲碘补充剂调整的多变量线性回归显示，UIC 与血清 TSH 水平的对数转换呈显著正相关（β=0.003：95%置信区间（CI）=0.0001-0.005；p=0.028）。
德国东北部的新生儿碘供应充足。这表明，即使最近的成人研究可能表明存在轻度碘缺乏，但德国其他地区的新生儿也有可能获得充足的碘供应。
