丹麦孕妇和哺乳期妇女的碘状况，包括对尿碘状况评估中一些挑战的研究。
Iodine status in Danish pregnant and breastfeeding women including studies of some challenges in urinary iodine status evaluation.
作者信息
Andersen Stine Linding, Sørensen Louise Kolding, Krejbjerg Anne, Møller Margrethe, Klitbo Ditte Marie, Nøhr Susanne Backman, Pedersen Klaus Michael, Laurberg Peter
机构信息
Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark.
出版信息
J Trace Elem Med Biol. 2015;31:285-9. doi: 10.1016/j.jtemb.2014.11.004. Epub 2014 Dec 2.
Denmark was previously iodine deficient with regional differences. Moderate iodine deficiency appeared in West Denmark and mild iodine deficiency in East Denmark and also Danish pregnant and breastfeeding women suffered from iodine deficiency. The Danish mandatory iodine fortification of salt was introduced in the year 2000 and has increased iodine intake in the Danish population. However, median urinary iodine concentration in the general population and in pregnant and breastfeeding women is still below the level recommended, corresponding to mild iodine deficiency. Certain characteristics may challenge the evaluation of urinary iodine status in pregnancy and during breastfeeding. This review also addresses methodological challenges related to spot urine sampling conditions and the use of iodine supplement and discusses the use of non-pregnant population groups as a proxy for iodine intake in pregnant women.
丹麦以前存在碘缺乏问题，且存在地区差异。丹麦西部出现中度碘缺乏，东部为轻度碘缺乏，丹麦的孕妇和哺乳期妇女也存在碘缺乏情况。2000年丹麦实行了强制性食盐碘强化措施，这增加了丹麦人群的碘摄入量。然而，普通人群以及孕妇和哺乳期妇女的尿碘中位数浓度仍低于推荐水平，相当于轻度碘缺乏。某些特征可能对孕期和哺乳期尿碘状况的评估构成挑战。本综述还探讨了与即时尿样采集条件以及碘补充剂使用相关的方法学挑战，并讨论了将非孕妇人群作为孕妇碘摄入量替代指标的用途。
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