探索β-肾上腺素能受体激酶-1与心力衰竭身体症状之间的关系。
Exploring the relationship between β-adrenergic receptor kinase-1 and physical symptoms in heart failure.
作者信息
Denfeld Quin E, Mudd James O, Hasan Wohaib, Gelow Jill M, Hiatt Shirin O, Winters-Stone Kerri, Lee Christopher S
机构信息
Oregon Health & Science University School of Nursing, Portland, OR, USA.
Oregon Health & Science University Knight Cardiovascular Institute, Portland, OR, USA.
出版信息
Heart Lung. 2018 Jul-Aug;47(4):281-284. doi: 10.1016/j.hrtlng.2018.05.003. Epub 2018 May 24.
BACKGROUND
The relationship between physical heart failure (HF) symptoms and pathophysiological mechanisms is unclear.
OBJECTIVE
To quantify the relationship between plasma β-adrenergic receptor kinase-1 (βARK1) and physical symptoms among adults with HF.
METHODS
We performed a secondary analysis of data collected from two studies of adults with HF. Plasma βARK1 was quantified using an enzyme-linked immunosorbent assay. Physical symptoms were measured with the HF Somatic Perception Scale (HFSPS). Generalized linear modeling was used to quantify the relationship between βARK1 and HFSPS scores.
RESULTS
The average age (n = 94) was 54.5 ± 13.1 years, 76.6% were male, and a majority (83.0%) had Class III or IV HF. βARK1 was significantly associated with HFSPS scores (β = 0.22 ± 0.10, p = 0.038), adjusting for other predictors of physical symptoms (model R = 0.250, F(7, 70) = 3.34, p = 0.004).
CONCLUSIONS
Higher βARK1 is associated with worse physical HF symptoms, pinpointing a potential pathophysiologic underpinning.
背景
心力衰竭（HF）的身体症状与病理生理机制之间的关系尚不清楚。
目的
量化血浆β-肾上腺素能受体激酶-1（βARK1）与成年HF患者身体症状之间的关系。
方法
我们对两项成年HF患者研究收集的数据进行了二次分析。使用酶联免疫吸附测定法对血浆βARK1进行定量。用HF躯体感知量表（HFSPS）测量身体症状。采用广义线性模型量化βARK1与HFSPS评分之间的关系。
结果
平均年龄（n = 94）为54.5±13.1岁，76.6%为男性，大多数（83.0%）患有Ⅲ级或Ⅳ级HF。在调整身体症状的其他预测因素后，βARK1与HFSPS评分显著相关（β = 0.22±0.10，p = 0.038）（模型R = 0.250，F(7, 70) = 3.34，p = 0.004）。
结论
较高的βARK1与更严重的HF身体症状相关，确定了潜在的病理生理基础。
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