Kinnos Inc., 760 Parkside Avenue, Suite 215, Brooklyn, NY 11226.
Kinnos Inc., 760 Parkside Avenue, Suite 215, Brooklyn, NY 11226.
Am J Infect Control. 2018 Nov;46(11):1254-1261. doi: 10.1016/j.ajic.2018.04.223. Epub 2018 May 24.
A novel color additive colorizes chlorine disinfectants blue to improve visibility and enhance spray surface coverage, and it fades to colorless to indicate elapsed contact time. We investigated its interactions with 3 chlorine disinfectants to determine if the additive would adversely affect the disinfectants' antimicrobial efficacy or skin safety.
We tested 0.5% sodium hypochlorite, 0.2% calcium hypochlorite, and 0.5% sodium dichloroisocyanurate (NaDCC) alone versus with color additive. An independent laboratory tested efficacy against Staphylococcus aureus, Pseudomonas aeruginosa, Vibrio cholerae, and human coronavirus 229E. An independent laboratory also tested direct skin irritation.
Chlorine disinfectants with and without color additive achieved equal levels of efficacy against the tested pathogens. Against S. aureus, 0.5% sodium hypochlorite with and without color additive met Environmental Protection Agency criteria for disinfection success. Against human coronavirus 229E, 0.5% sodium hypochlorite alone failed disinfection success criteria, whereas 0.5% sodium hypochlorite with color additive achieved full viral inactivation (≥4.50 log reduction). Against V. cholerae, 0.2% calcium hypochlorite alone and with color additive achieved 5.99 log and >6.03 log reductions, respectively. Against S. aureus and P. aeruginosa, 0.5% NaDCC with and without color additive achieved >4.9 log and >3.54 log reductions, respectively. All 3 chlorine disinfectants with color additive tested as negligible skin irritants.
This color additive can be combined with chlorine disinfectants without adversely affecting antimicrobial efficacy or skin safety.
一种新型的颜色添加剂可将氯消毒剂染成蓝色，以提高可见度并增强喷雾表面覆盖范围，且其褪色为无色以指示接触时间的流逝。我们研究了其与 3 种氯消毒剂的相互作用，以确定该添加剂是否会对消毒剂的抗菌功效或皮肤安全性产生不利影响。
我们单独测试了 0.5%次氯酸钠、0.2%次氯酸钙和 0.5%二氯异氰尿酸钠（NaDCC），以及它们与颜色添加剂的混合物，以测试对金黄色葡萄球菌、铜绿假单胞菌、霍乱弧菌和人冠状病毒 229E 的功效。一个独立的实验室还测试了直接皮肤刺激。
有和没有颜色添加剂的氯消毒剂对测试病原体均具有相同水平的功效。对于金黄色葡萄球菌，有和没有颜色添加剂的 0.5%次氯酸钠符合环境保护署消毒成功的标准。对于人冠状病毒 229E，单独的 0.5%次氯酸钠未能达到消毒成功标准，而有颜色添加剂的 0.5%次氯酸钠则实现了完全的病毒灭活（≥4.50 对数减少）。对于霍乱弧菌，单独使用 0.2%次氯酸钙和添加颜色添加剂分别实现了 5.99 对数和>6.03 对数的减少。对于金黄色葡萄球菌和铜绿假单胞菌，有和没有颜色添加剂的 0.5%NaDCC 分别实现了>4.9 对数和>3.54 对数的减少。所有 3 种含有颜色添加剂的氯消毒剂测试结果均为轻微皮肤刺激剂。
这种颜色添加剂可以与氯消毒剂结合使用，而不会对其抗菌功效或皮肤安全性产生不利影响。
