Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea.
Research Unit, Green Cross Veterinary Products, Yongin 17066, Republic of Korea.
Int J Infect Dis. 2018 Jul;72:22-24. doi: 10.1016/j.ijid.2018.05.011. Epub 2018 May 25.
We hereby report the first characterization of mcr-3 gene from healthy animals in South Korea. Out of 636 E. coli isolates, collected between 2014- 2017, nine colistin resistant isolates were screened for the presence of mcr-1 and mcr-3 genes. Nine (1.4%) isolates had shown resistance for colistin and among them three and two isolates were mcr-1 harboring and mcr-3 harboring strains, respectively. All the colistin-resistant isolates were multidrug-resistant. mcr-1 and mcr-3 genes were confirmed to be transferred to a recipient E. coli J53 AZ.
我们特此报告了 mcr-3 基因在韩国健康动物中的首次特征描述。在 2014 年至 2017 年间收集的 636 株大肠杆菌分离株中，筛选了 9 株对粘菌素耐药的分离株，以检测 mcr-1 和 mcr-3 基因的存在。9 株（1.4%）分离株对粘菌素表现出耐药性，其中 3 株和 2 株分别为 mcr-1 携带株和 mcr-3 携带株。所有对粘菌素耐药的分离株均为多药耐药株。mcr-1 和 mcr-3 基因被证实可转移到受体大肠杆菌 J53 AZ 中。
