韩国人类大肠杆菌感染中产MCR-1质粒的检测及遗传特征
Detection and genetic features of MCR-1-producing plasmid in human Escherichia coli infection in South Korea.
作者信息
Kim Eun Sil, Chong Yong Pil, Park Su-Jin, Kim Mi-Na, Kim Sung-Han, Lee Sang-Oh, Choi Sang-Ho, Woo Jun Hee, Jeong Jin-Yong, Kim Yang Soo
机构信息
Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
出版信息
Diagn Microbiol Infect Dis. 2017 Oct;89(2):158-160. doi: 10.1016/j.diagmicrobio.2017.06.020. Epub 2017 Jul 2.
The plasmid-mediated colistin resistance gene, mcr-1, was identified for the first time from a hospitalized patient in South Korea. The mcr-1 gene was successfully transferred to E. coli J53 recipient and conferred resistance to colistin in the recipient. The mcr-1-harboring plasmid possessed a typical IncI2 group and did not have the mcr-1-associated ISApl1 element.
质粒介导的黏菌素耐药基因mcr-1首次从韩国一名住院患者中鉴定出来。mcr-1基因成功转移至大肠杆菌J53受体菌，并使受体菌获得对黏菌素的耐药性。携带mcr-1的质粒具有典型的IncI2菌群，且没有与mcr-1相关的ISApl1元件。
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