Yang Yong-Qiang, Li Yun-Xia, Song Tao, Yang Yan-Xian, Jiang Wei, Zhang An-Yun, Guo Xin-Yi, Liu Bi-Hui, Wang Yong-Xiang, Lei Chang-Wei, Xiang Rong, Wang Hong-Ning
Animal Disease Prevention and Food Safety, Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, China.
Microbiology and Metabolic Engineering of Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, China.
Antimicrob Agents Chemother. 2017 Apr 24;61(5). doi: 10.1128/AAC.01204-16. Print 2017 May.
The gene was detected in 5.11% (58/1136) of isolates of chicken origin from 13 provinces in China. A novel variant, named , encoding an Ile-to-Val functional variant of MCR-1 was identified in a sequence type 155 (ST155) strain. An -containing IncI2 plasmid, pHeN867 (60,757 bp), was identified. The transfer of pHeN867 led to a 32-fold increase in the MIC of colistin in the recipient, exhibiting an effect on colistin resistance that was similar to that of .
在中国13个省份的鸡源分离株中，该基因在5.11%（58/1136）的分离株中被检测到。在一株序列型155（ST155）菌株中鉴定出一种名为 的新型变体，其编码MCR-1的异亮氨酸到缬氨酸功能变体。鉴定出一个含有 的IncI2质粒pHeN867（60,757 bp）。pHeN867的转移导致受体中粘菌素的最低抑菌浓度（MIC）增加32倍，表现出与 对粘菌素耐药性相似的作用。
