Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Dianli Road No. 8, Zhenjiang, 212012, China.
Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, Jiangsu University School of Medicine, Zhenjiang, China.
Immunol Res. 2018 Jun;66(3):313-322. doi: 10.1007/s12026-018-9000-0.
Exosomes are small membrane vesicles of endocytic origin that are secreted by most cells. They are composed of a lipid bilayer containing transmembrane proteins and enclosing cytosolic proteins and RNA, mediating intercellular communication between different cell types in the body, and thus influencing various physiological and pathological functions of both recipient and parent cells. For their nanolevel structures with a stable nature and various biological functions, studies of exosomes have been the subject of increasing interest in the past few years. It is widely known that different T cell subsets play important roles in cellular and humoral immunity, and their exosomes were also reported to exert similar biological functions. While several groups reported the secretion of exosomes by various T cells, the systematic summary involved in these exosomes are deficient. In this review, we will summarize the structure and functions of exosomes derived from T cells in recent reports, discuss emerging therapeutic opportunities, and consider the associated challenges.
外泌体是内体起源的小膜囊泡，大多数细胞都会分泌它们。它们由一个含有跨膜蛋白的脂质双层组成，其中包含胞质蛋白和 RNA，介导体内不同细胞类型之间的细胞间通讯，从而影响受体和供体细胞的各种生理和病理功能。由于其具有稳定性质和多种生物功能的纳米级结构，近年来对外泌体的研究越来越受到关注。众所周知，不同的 T 细胞亚群在细胞和体液免疫中发挥重要作用，它们的外泌体也被报道具有类似的生物学功能。虽然有几个小组报道了各种 T 细胞分泌外泌体，但这些外泌体的系统总结还很缺乏。在这篇综述中，我们将总结最近报道的 T 细胞衍生的外泌体的结构和功能，讨论新兴的治疗机会，并考虑相关的挑战。
