College of Pharmacy and Inje Institute of Pharmaceutical Sciences and Research, Inje University, 197 Injero, Gimhae, Gyeongnam, 621-749, Republic of Korea.
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, 501 Jinju Daero, Jinju, Gyeongnam, 660-751, Republic of Korea.
Arch Pharm Res. 2018 Jun;41(6):594-616. doi: 10.1007/s12272-018-1038-y. Epub 2018 May 26.
Cancer is a leading cause of death worldwide. Despite many advances in the field of cancer therapy, an effective cure is yet to be found. As a more potent alternative for the conventional small molecule anti-cancer drugs, pro-apoptotic peptides have emerged as a new class of anticancer agents. By interaction with certain members in the apoptotic pathways, they could effectively kill tumor cells. However, there remain bottleneck challenges for clinical application of these pro-apoptotic peptides in cancer therapy. In this review, we will overview the developed pro-apoptotic peptides and outline the widely adopted molecular-based and nanoparticle-based strategies to enhance their anti-tumor effects.
癌症是全球主要的死亡原因。尽管癌症治疗领域取得了许多进展，但仍未找到有效的治愈方法。作为传统小分子抗癌药物的更有效替代品，促凋亡肽已成为一类新的抗癌药物。通过与凋亡途径中的某些成员相互作用，它们可以有效地杀死肿瘤细胞。然而，在癌症治疗中应用这些促凋亡肽仍存在临床应用的瓶颈挑战。在这篇综述中，我们将概述已开发的促凋亡肽，并概述广泛采用的基于分子和基于纳米颗粒的策略，以增强它们的抗肿瘤效果。
