Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Molecular Small Animal Imaging Center, Catholic University Leuven, Leuven, Belgium.
CNS Neurosci Ther. 2019 Jan;25(1):36-46. doi: 10.1111/cns.12976. Epub 2018 May 27.
A possible target for stroke management is modulation of neuroinflammation. Evidence suggests that food components may exert anti-inflammatory properties and thus may reduce stroke-induced brain damage.
To investigate the efficacy of a diet, containing anti-inflammatory ingredients, as treatment for focal ischemic brain damage induced by photothrombotic stroke in the somatosensory cortex of rats.
Brain lesions were surrounded by strong astrogliosis on both day 7 and day 21 after stroke and were accompanied by a trend toward globally decreased glucose metabolism on day 7. The investigational diet applied 2 weeks before the ischemia did not affect astrocyte activation on day 7, but reduced it at day 21. The investigational diet applied immediately after the ischemia, increased astrocyte activation on day 7 and completely reversed this effect on day 21. Moreover, postischemic intervention increased glucose metabolism in somatosensory cortex ipsilateral to the lesion on day 7.
This study reveals potentially beneficial effects of a diet containing elevated amounts of anti-inflammatory nutrients on the recovery from ischemic brain damage. Therefore, dietary intervention can be considered as an adjuvant therapy for recovery from this brain pathology.
脑卒中管理的一个可能靶点是神经炎症的调节。有证据表明，食物成分可能具有抗炎特性，从而可能减轻卒中引起的脑损伤。
研究含有抗炎成分的饮食作为治疗大鼠体感皮层光血栓性卒中引起的局灶性缺血性脑损伤的疗效。
卒中后第 7 天和第 21 天，脑损伤周围有强烈的星形胶质细胞增生，并且第 7 天的葡萄糖代谢呈整体下降趋势。在缺血前 2 周应用的试验饮食并未影响第 7 天的星形胶质细胞激活，但在第 21 天则减少了激活。缺血后立即应用的试验饮食增加了第 7 天对侧体感皮层的星形胶质细胞激活，并在第 21 天完全逆转了这种作用。此外，缺血后干预增加了对侧体感皮层的葡萄糖代谢。
本研究揭示了富含抗炎营养素的饮食对缺血性脑损伤恢复的潜在有益作用。因此，饮食干预可以被认为是这种脑病理恢复的辅助治疗。
