Boerema Ate S, Heesterbeek Marelle, Boersma Selma A, Schoemaker Regien, de Vries Erik F J, van Heuvelen Marieke J G, Van der Zee Eddy A
Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Groningen Institute for Evolutionary Life Sciences (GELIFES), Molecular Neurobiology, University of Groningen, Groningen, the Netherlands.
Dose Response. 2018 Dec 4;16(4):1559325818811756. doi: 10.1177/1559325818811756. eCollection 2018 Oct-Dec.
The biological consequences of mechanical whole body vibration (WBV) on the brain are not well documented. The aim of the current study was to further investigate the effects of a 5-week WBV intervention on brain functions. Mice (C57Bl/6J males, age 15 weeks) were exposed to 30 Hz WBV sessions (10 minutes per day, 5 days per week, for a period of 5 weeks; n = 10). Controls received the same intervention without the actual vibration (n = 10). Humans (both genders, age ranging from 44-99 years) were also exposed to daily sessions of 30 Hz WBV (4 minutes per day, 4 days per week, for a period of 5 weeks; n = 18). Controls received the same protocol using a 1 Hz protocol (n = 16). Positron emission tomography imaging was performed in the mice, and revealed that glucose uptake was not changed as a consequence of the 5-week WBV intervention. Whole body vibration did, however, improve motor performance and reduced arousal-induced home cage activity. Cognitive tests in humans revealed a selective improvement in the Stroop Color-Word test. Taken together, it is concluded that WBV is a safe intervention to improve brain functioning, although the subtle effects suggest that the protocol is as yet suboptimal.
机械性全身振动（WBV）对大脑的生物学影响尚无充分记录。本研究的目的是进一步探究为期5周的WBV干预对脑功能的影响。将小鼠（C57Bl/6J雄性，15周龄）暴露于30Hz的WBV中（每天10分钟，每周5天，持续5周；n = 10）。对照组接受相同干预，但无实际振动（n = 10）。人类（男女皆有，年龄在44 - 99岁之间）也每天接受30Hz的WBV（每天4分钟，每周4天，持续5周；n = 18）。对照组使用1Hz方案接受相同方案（n = 16）。对小鼠进行了正电子发射断层扫描成像，结果显示，为期5周的WBV干预并未改变葡萄糖摄取。然而，全身振动确实改善了运动性能，并减少了觉醒引起的笼内活动。对人类进行的认知测试显示，在Stroop颜色-文字测试中有选择性的改善。综上所述，得出结论：WBV是一种改善脑功能的安全干预措施，尽管其细微效果表明该方案尚不优化。
