Dokunmu Titilope Modupe, Yakubu Omolara Faith, Adebayo Abiodun Humphrey, Olasehinde Grace Iyabo, Chinedu Shalom Nwodo
Department of Biochemistry, Covenant University, Ota, Nigeria.
Covenant University Public Health and Wellbeing Research Group (CUPHWERG), Ota, Nigeria.
Int J Hypertens. 2018 Apr 1;2018:6898527. doi: 10.1155/2018/6898527. eCollection 2018.
The burden of hypertension, a silent killer, continues to increase in low- and middle-income countries. This study evaluated blood pressure (BP) in healthy adults to determine their risk of developing hypertension and to reduce associated morbidity of the disease. Overall, 182 subjects aged >16 years participated in the study. Systolic (SBP) and diastolic blood pressure (DBP) was measured after a resting period using mercury sphygmomanometer. Random blood glucose (RBG) concentration was also determined. Regression models were used to determine risk of high BP with values < 0.05 indicating statistical difference. Prehypertension was present in 36.8% population and high BP in 31% individuals with hypertensive symptoms. DBP ≥ 90 mmHg was prevalent in the undiagnosed group, while diabetes comorbidity was detected in only 4 individuals. High BP or diabetes was not detected in those <20 year olds. Age > 35 years was an independent risk (likelihood ratio: 22.56, < 0.0001); this increases to 26.48 ( < 0.0001) in the presence prediabetes and RBG > 100 mg/dl. Undiagnosed hypertension rate is high in the study area, and urgent interventions for large scale screening and management of the disease are required to reduce the burden of hypertension in Nigeria.
高血压这一沉默杀手在低收入和中等收入国家的负担持续增加。本研究评估了健康成年人的血压，以确定他们患高血压的风险并降低该疾病的相关发病率。总体而言，182名年龄大于16岁的受试者参与了该研究。在休息一段时间后，使用汞柱血压计测量收缩压（SBP）和舒张压（DBP）。还测定了随机血糖（RBG）浓度。使用回归模型确定高血压风险，P值<0.05表示有统计学差异。36.8%的人群存在高血压前期，31%有高血压症状的个体患有高血压。DBP≥90 mmHg在未确诊组中很普遍，而仅在4名个体中检测到糖尿病合并症。在20岁以下的人群中未检测到高血压或糖尿病。年龄>35岁是一个独立风险因素（似然比：22.56，P<0.0001）；在存在糖尿病前期且RBG>100 mg/dl的情况下，该风险增加到26.48（P<0.0001）。研究地区未确诊高血压的比例很高，需要采取紧急干预措施进行大规模筛查和疾病管理，以减轻尼日利亚的高血压负担。
