白细胞介素-37 综述：功能、受体及在疾病中的作用。
Reviews of Interleukin-37: Functions, Receptors, and Roles in Diseases.
机构信息
Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, No. 324 Jingwuweiqi Road, Jinan, Shandong 250021, China.
出版信息
Biomed Res Int. 2018 Apr 1;2018:3058640. doi: 10.1155/2018/3058640. eCollection 2018.
Abstract
Interleukin-37 (IL-37) is an IL-1 family cytokine discovered in recent years and has 5 different isoforms. As an immunosuppressive factor, IL-37 can suppress excessive immune response. IL-37 plays a role in protecting the body against endotoxin shock, ischemia-reperfusion injury, autoimmune diseases, and cardiovascular diseases. In addition, IL-37 has a potential antitumor effect. IL-37 and its receptors may serve as novel targets for the study, diagnosis, and treatment of immune-related diseases and tumors.
摘要
白细胞介素-37（IL-37）是近年来发现的一种白细胞介素 1 家族细胞因子，具有 5 种不同的亚型。作为一种免疫抑制因子，IL-37 可以抑制过度的免疫反应。IL-37 在保护机体免受内毒素休克、缺血再灌注损伤、自身免疫性疾病和心血管疾病方面发挥作用。此外，IL-37 具有潜在的抗肿瘤作用。IL-37 及其受体可能成为免疫相关疾病和肿瘤研究、诊断和治疗的新靶点。
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