特发性震颤与抑郁症。
Essential tremor and depression.
作者信息
Aslam Sana, Zhang Nan, Adler Charles H, Caviness John N, Driver-Dunckley Erika, Mehta Shyamal H, Sabbagh Marwan N, Belden Christine, Zamrini Edward, Beach Thomas G, Shill Holly A
机构信息
Barrow Neurological Institute, Phoenix, AZ.
Mayo Clinic Arizona, Scottsdale, AZ.
出版信息
Mov Disord Clin Pract. 2017 Nov-Dec;4(6):838-842. doi: 10.1002/mdc3.12530. Epub 2017 Jul 17.
INTRODUCTION
Depression and neuropsychiatric disorders in individuals with essential tremor (ET) are not well characterized in the literature.
METHODS
We compared 104 ET subjects with 481 non-ET controls involved in the Arizona Study of Aging and Neurodegenerative Disorders. An analysis of baseline depression scales and neuropsychiatric inventory (NPI) was done between the two groups. Comparisons were made additionally within the ET group based on tremor severity, duration of tremor and age of onset.
RESULTS
There were no significant differences among each of the scales between the ET and non-ET groups. There were no significant differences in the ET group above and below the median tremor duration. Additionally, no differences were found in the ET group based on objective measures of tremor severity, age of onset, or those with subjectively distressing tremor compared with those without.
CONCLUSION
There were no significant differences in depressive symptoms between ET and non-ET groups. Furthermore, no correlation was found between depressive symptoms in ET groups based on tremor severity, duration, or age of onset.
引言
原发性震颤（ET）患者的抑郁及神经精神障碍在文献中尚无充分描述。
方法
我们将参与亚利桑那州衰老与神经退行性疾病研究的104名ET患者与481名非ET对照者进行了比较。对两组的基线抑郁量表和神经精神科问卷（NPI）进行了分析。此外，还在ET组内根据震颤严重程度、震颤持续时间和发病年龄进行了比较。
结果
ET组和非ET组之间各量表均无显著差异。震颤持续时间中位数以上和以下的ET组之间无显著差异。此外，根据震颤严重程度的客观测量、发病年龄，或与无主观困扰震颤者相比，有主观困扰震颤的ET组之间也未发现差异。
结论
ET组和非ET组之间的抑郁症状无显著差异。此外，基于震颤严重程度、持续时间或发病年龄，未发现ET组抑郁症状之间存在相关性。
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