特发性震颤、肌张力障碍和帕金森病中的淡漠：与正常对照的比较。
Apathy in essential tremor, dystonia, and Parkinson's disease: a comparison with normal controls.
机构信息
G.H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
出版信息
Mov Disord. 2012 Mar;27(3):432-4. doi: 10.1002/mds.24049. Epub 2011 Dec 19.
Abstract
BACKGROUND
Apathy, defined as decreased goal-directed activity, has been observed in Parkinson's disease. A number of cognitive/psychiatric features have been documented in essential tremor, yet we are unaware of studies of apathy.
METHODS
Using the Apathy Evaluation Scale (range = 18-72 [more apathy]), we compared 79 essential tremor cases, 20 dystonia cases, and 39 Parkinson's disease cases with 80 normal controls.
RESULTS
The score of the Apathy Evaluation Scale was higher in essential tremor, dystonia, and Parkinson's disease cases than controls (all P ≤ .04). Parkinson's disease cases had the highest scores. Analyses stratified by presence/absence of depressive symptoms indicated the presence of a group of apathetic but nondepressed cases.
CONCLUSIONS
Patients with Parkinson's disease, essential tremor, and dystonia had elevated apathy scores. Features of apathy seemed to occur in these conditions independent of depressive symptoms. The mechanistic basis for the apparent increased features of apathy in essential tremor and dystonia deserves further study.
摘要
背景
在帕金森病中观察到了冷漠，即目标导向活动减少。特发性震颤已记录了许多认知/精神特征，但我们不知道对冷漠的研究。
方法
使用淡漠评估量表（范围为 18-72 [更多冷漠]），我们比较了 79 例特发性震颤病例、20 例肌张力障碍病例和 39 例帕金森病病例与 80 例正常对照组。
结果
特发性震颤、肌张力障碍和帕金森病患者的淡漠评估量表评分高于对照组（均 P ≤.04）。帕金森病患者的评分最高。按是否存在抑郁症状进行分层分析表明，存在一组淡漠但不抑郁的病例。
结论
帕金森病、特发性震颤和肌张力障碍患者的淡漠评分升高。这些疾病中似乎存在与抑郁症状无关的冷漠特征。特发性震颤和肌张力障碍中明显增加的冷漠特征的机制基础值得进一步研究。
相似文献
1
Apathy in essential tremor, dystonia, and Parkinson's disease: a comparison with normal controls.特发性震颤、肌张力障碍和帕金森病中的淡漠：与正常对照的比较。
Mov Disord. 2012 Mar;27(3):432-4. doi: 10.1002/mds.24049. Epub 2011 Dec 19.
2
Nonmotor symptoms in essential tremor: Comparison with Parkinson's disease and normal control.特发性震颤的非运动症状：与帕金森病及正常对照的比较
J Neurol Sci. 2015 Feb 15;349(1-2):168-73. doi: 10.1016/j.jns.2015.01.012. Epub 2015 Jan 13.
3
Somatosensory temporal discrimination in Parkinson's disease, dystonia and essential tremor: Pathophysiological and clinical implications.帕金森病、肌张力障碍和特发性震颤的体感时间辨别：病理生理和临床意义。
Clin Neurophysiol. 2018 Sep;129(9):1849-1853. doi: 10.1016/j.clinph.2018.05.024. Epub 2018 Jun 27.
4
Depression symptoms in movement disorders: comparing Parkinson's disease, dystonia, and essential tremor.运动障碍中的抑郁症状：帕金森病、肌张力障碍和特发性震颤的比较
Mov Disord. 2007 Apr 15;22(5):666-72. doi: 10.1002/mds.21376.
5
Differential contributions of depression, apathy, and anxiety to neuropsychological performance in Parkinson's disease versus essential tremor.抑郁、淡漠和焦虑对帕金森病与特发性震颤患者神经心理学表现的不同影响。
J Clin Exp Neuropsychol. 2022 Nov;44(9):651-664. doi: 10.1080/13803395.2022.2157796. Epub 2023 Jan 4.
6
Parkinson's disease with and without preceding essential tremor-similar phenotypes: a pilot study.伴有和不伴有先前特发性震颤的帕金森病——相似表型：一项初步研究
J Neurol. 2014 May;261(5):884-8. doi: 10.1007/s00415-014-7285-z. Epub 2014 Mar 4.
7
Psychological symptoms after awake deep brain stimulation surgery in parkinson's disease, essential tremor, and dystonia.帕金森病、特发性震颤和肌张力障碍患者清醒状态下脑深部电刺激术后的心理症状
Eur Neuropsychopharmacol. 2024 Sep;86:13. doi: 10.1016/j.euroneuro.2024.05.005. Epub 2024 Jun 22.
8
Dissociating apathy and depression in Parkinson disease.区分帕金森病中的冷漠与抑郁
Neurology. 2006 Jul 11;67(1):33-8. doi: 10.1212/01.wnl.0000230572.07791.22.
9
Apathy and depression in Parkinson's disease: the Belgrade PD study report.帕金森病中的冷漠和抑郁：贝尔格莱德 PD 研究报告。
Parkinsonism Relat Disord. 2012 May;18(4):339-42. doi: 10.1016/j.parkreldis.2011.11.020. Epub 2011 Dec 13.
10
The prominent role of serotonergic degeneration in apathy, anxiety and depression in de novo Parkinson's disease.在新发帕金森病中，5-羟色胺能神经元退化在淡漠、焦虑和抑郁中起显著作用。
Brain. 2016 Sep;139(Pt 9):2486-502. doi: 10.1093/brain/aww162. Epub 2016 Aug 17.
引用本文的文献
1
Negative emotion modulates postural tremor variability in Parkinson's disease: A multimodal EEG and motion sensor study toward behavioral interventions.消极情绪调节帕金森病患者的姿势性震颤变异性：一项针对行为干预的多模态脑电图和运动传感器研究。
IBRO Neurosci Rep. 2025 Apr 11;18:663-671. doi: 10.1016/j.ibneur.2025.04.003. eCollection 2025 Jun.
2
Differential contributions of depression, apathy, and anxiety to neuropsychological performance in Parkinson's disease versus essential tremor.抑郁、淡漠和焦虑对帕金森病与特发性震颤患者神经心理学表现的不同影响。
J Clin Exp Neuropsychol. 2022 Nov;44(9):651-664. doi: 10.1080/13803395.2022.2157796. Epub 2023 Jan 4.
3
Essential tremor patients experience significant burden beyond tremor: A systematic literature review.特发性震颤患者经历的负担远超震颤：一项系统文献综述。
Front Neurol. 2022 Jul 22;13:891446. doi: 10.3389/fneur.2022.891446. eCollection 2022.
4
Clinical Characteristics of Essential Tremor in South India: A Hospital-Based Cohort Study.印度南部特发性震颤的临床特征：一项基于医院的队列研究。
J Neurosci Rural Pract. 2019 Apr-Jun;10(2):245-249. doi: 10.4103/jnrp.jnrp_348_18.
5
The Prevalence and Correlation of Non-motor Symptoms in Adult Patients with Idiopathic Focal or Segmental Dystonia.成年特发性局灶性或节段性肌张力障碍患者非运动症状的患病率及相关性
Tremor Other Hyperkinet Mov (N Y). 2019 Feb 4;9:596. doi: 10.7916/fhnv-v355. eCollection 2019.
6
Essential Tremor and Parkinson's Disease: Exploring the Relationship.特发性震颤与帕金森病：探索两者关系
Tremor Other Hyperkinet Mov (N Y). 2019 Jan 9;8:589. doi: 10.7916/D8MD0GVR. eCollection 2018.
7
Essential tremor and depression.特发性震颤与抑郁症。
Mov Disord Clin Pract. 2017 Nov-Dec;4(6):838-842. doi: 10.1002/mdc3.12530. Epub 2017 Jul 17.
8
Cognitive, Emotional, and Auto-Activation Dimensions of Apathy in Parkinson's Disease.帕金森病中冷漠的认知、情感和自动激活维度
Front Behav Neurosci. 2017 Nov 21;11:230. doi: 10.3389/fnbeh.2017.00230. eCollection 2017.
9
Emotion modulation of the startle reflex in essential tremor: Blunted reactivity to unpleasant and pleasant pictures.原发性震颤中惊吓反射的情绪调节：对不愉快和愉快图片的反应迟钝。
Parkinsonism Relat Disord. 2017 Jan;34:54-58. doi: 10.1016/j.parkreldis.2016.11.003. Epub 2016 Nov 17.
10
Depressive symptoms can amplify embarrassment in essential tremor.抑郁症状会加重原发性震颤患者的尴尬情绪。
J Clin Mov Disord. 2016 Jul 15;3:11. doi: 10.1186/s40734-016-0039-6. eCollection 2016.
本文引用的文献
1
Impact of apathy on health-related quality of life in recently diagnosed Parkinson's disease: the ANIMO study.近期诊断为帕金森病患者的冷漠对健康相关生活质量的影响：ANIMO 研究。
Mov Disord. 2012 Feb;27(2):211-8. doi: 10.1002/mds.23872. Epub 2011 Jul 20.
2
Measuring apathy after traumatic brain injury: Psychometric properties of the Apathy Evaluation Scale and the Frontal Systems Behavior Scale.创伤性脑损伤后冷漠的测量：冷漠评估量表和额叶系统行为量表的心理测量特性。
Brain Inj. 2009 Dec;23(13-14):999-1007. doi: 10.3109/02699050903379347.
3
Consistency of clinical diagnosis of dementia in NEDICES: A population-based longitudinal study in Spain.NEDICES 中痴呆临床诊断的一致性：西班牙一项基于人群的纵向研究。
J Geriatr Psychiatry Neurol. 2009 Dec;22(4):246-55. doi: 10.1177/0891988709335794. Epub 2009 May 5.
4
Proposed diagnostic criteria for apathy in Alzheimer's disease and other neuropsychiatric disorders.阿尔茨海默病及其他神经精神障碍中淡漠的拟诊标准。
Eur Psychiatry. 2009 Mar;24(2):98-104. doi: 10.1016/j.eurpsy.2008.09.001. Epub 2009 Feb 7.
5
Executive dysfunction and neuropsychiatric symptoms predict lower health status in essential tremor.执行功能障碍和神经精神症状预示着特发性震颤患者的健康状况较差。
Cogn Behav Neurol. 2008 Mar;21(1):28-33. doi: 10.1097/WNN.0b013e3181684414.
6
Elevated blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor.原发性震颤患者血液中哈尔满（1-甲基-9H-吡啶并[3,4-b]吲哚）浓度升高。
Neurotoxicology. 2008 Mar;29(2):294-300. doi: 10.1016/j.neuro.2007.12.001. Epub 2007 Dec 27.
7
Essential tremor: emerging views of a common disorder.特发性震颤：一种常见疾病的新观点
Nat Clin Pract Neurol. 2006 Dec;2(12):666-78; quiz 2p following 691. doi: 10.1038/ncpneuro0347.
8
Dissociating apathy and depression in Parkinson disease.区分帕金森病中的冷漠与抑郁
Neurology. 2006 Jul 11;67(1):33-8. doi: 10.1212/01.wnl.0000230572.07791.22.
9
Elevation of blood beta-carboline alkaloids in essential tremor.原发性震颤患者血液中β-咔啉生物碱水平升高。
Neurology. 2002 Dec 24;59(12):1940-4. doi: 10.1212/01.wnl.0000038385.60538.19.
10
Apathy in Parkinson's disease.帕金森病中的淡漠
J Neurol Neurosurg Psychiatry. 2002 Dec;73(6):636-42. doi: 10.1136/jnnp.73.6.636.
Zotero 插件