Desnoyers Mélissa, Gilbert Kim, Madingou Ness, Gagné Marc-André, Daneault Caroline, Des Rosiers Christine, Rousseau Guy
a CIUSSS du nord de l'île de Montréal, Hôpital Sacré-Cœur, Montréal, QC H4J 1C5, Canada.
b Département de pharmacologie et de physiologie, Université de Montréal, Montréal, QC H3C 3J7, Canada.
Can J Physiol Pharmacol. 2018 Sep;96(9):916-921. doi: 10.1139/cjpp-2018-0043. Epub 2018 May 28.
The present study was designed to ascertain the effects of 3 diets with different omega-3/6 fatty acid ratios on infarct size and the modifications that these diets induce in the lipid composition of cardiac tissue. Sprague-Dawley rats were fed omega-3/6 fatty acid diets with 1:1, 1:5, or 1:20 ratios for at least 10 days, followed by occlusion of the left anterior descending artery for 40 min and 24 h of reperfusion. Infarct size was significantly smaller in the 1:1 group than in the other groups. Significantly higher concentrations of the omega-3 fatty acids eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid were found in the 1:1 group than in the other groups. Omega-6 polyunsaturated fatty acid levels were similar between groups, although they were higher in the 1:5 and 1:20 groups than in the 1:1 group. Margaric acid concentrations were higher in the 1:1 group than in the other groups. Docosahexaenoic acid levels in cardiac tissue and infarct size were significantly correlated with no other significant links being apparent. The present study indicated that a 1:1 omega-3/6 fatty acid ratio protected against ischemia and was associated with increased omega-3 fatty acid composition of cardiac tissue.
本研究旨在确定三种不同ω-3/ω-6脂肪酸比例的饮食对梗死面积的影响，以及这些饮食对心脏组织脂质成分的改变。将斯普拉格-道利大鼠喂食ω-3/ω-6脂肪酸比例为1:1、1:5或1:20的饮食至少10天，随后结扎左冠状动脉前降支40分钟并再灌注24小时。1:1组的梗死面积显著小于其他组。1:1组中ω-3脂肪酸二十碳五烯酸、二十二碳五烯酸和二十二碳六烯酸的浓度显著高于其他组。各组间ω-6多不饱和脂肪酸水平相似，尽管1:5和1:20组高于1:1组。十七烷酸浓度在1:1组高于其他组。心脏组织中的二十二碳六烯酸水平与梗死面积显著相关，未发现其他明显的显著关联。本研究表明，1:1的ω-3/ω-6脂肪酸比例可预防缺血，并与心脏组织中ω-3脂肪酸组成增加有关。
