Hudman J F, Costa N D, Robinson W F
School of Business and Technology, MacArthur Institute of Higher Education, Campbelltown, New South Wales, Australia.
J Trace Elem Electrolytes Health Dis. 1988 Jun;2(2):105-9.
The severity of selenium dependent nutritional myopathy in weaner sheep was markedly increased by the ruminal infusion of soluble phosphate (6.0 g d-1). Liver selenium concentration was also significantly lower in the sheep infused with sodium phosphate than in sheep fed the same diet and infused with sodium chloride. There were no significant differences in the selenium concentrations of other tissues examined (kidney, heart, skeletal muscle, blood). Blood glutathione peroxidase (GSH.Px) activity in the sheep affected with nutritional myopathy was considerably higher than values generally accepted to indicate a selenium deficiency. The results indicated that there was an interaction in the animal between selenium and phosphate leading to lower liver selenium concentrations. Results obtained from sheep intraruminally dosed with 75[Se]selenate suggested that an interaction between selenium and phosphate could also occur in the gastrointestinal tract.
断奶羔羊中，瘤胃注入可溶性磷酸盐（6.0克/天）显著加重了硒依赖性营养性肌病的严重程度。与饲喂相同日粮并注入氯化钠的绵羊相比，注入磷酸钠的绵羊肝脏硒浓度也显著更低。在所检测的其他组织（肾脏、心脏、骨骼肌、血液）的硒浓度方面，未发现显著差异。患营养性肌病绵羊的血液谷胱甘肽过氧化物酶（GSH.Px）活性显著高于通常认为表明硒缺乏的值。结果表明，动物体内硒和磷酸盐之间存在相互作用，导致肝脏硒浓度降低。对瘤胃内注入75[Se]硒酸盐的绵羊所获得的结果表明，胃肠道中也可能发生硒和磷酸盐之间的相互作用。
