Allen J G, Steele P, Masters H G, D'Antuono M F
Aust Vet J. 1986 Jan;63(1):8-13. doi: 10.1111/j.1751-0813.1986.tb02862.x.
The effectiveness of various treatments upon, and pathological and biochemical changes in, ovine weaner nutritional myopathy were observed. Clinical myopathy was already apparent in the sheep at the start of the study, and they were fed decreasing amounts of a ration containing low levels of selenium and alpha-tocopherol, and periodically deprived of water. In spite of this management there was a spontaneous remission of the clinical myopathy in the sheep, but a subclinical myopathy was identified in some of the sheep at the end of the trail. The conclusions were that the myopathy was not caused by a low dietary intake of selenium and/or alpha-tocopherol alone, that alpha-tocopherol was involved in the aetiology, that alpha-tocopherol was completely effective and selenium possibly partially effective in treating it, and that the condition may be a Type II muscle fibre disease. Data on plasma creatine phosphokinase and erythrocyte glutathione peroxidase activities, and terminal liver selenium and alpha-tocopherol concentrations are presented, and their roles in the diagnosis of ovine weaner nutritional myopathy discussed.
观察了各种治疗方法对绵羊断奶期营养性肌病的疗效以及该病的病理和生化变化。在研究开始时，绵羊的临床肌病已很明显，给它们饲喂含低水平硒和α-生育酚的日粮，且日粮量逐渐减少，并定期断水。尽管采取了这种管理方式，绵羊的临床肌病仍自发缓解，但在试验结束时，部分绵羊被发现存在亚临床肌病。结论是，肌病并非仅由日粮中硒和/或α-生育酚摄入量低所致，α-生育酚参与了病因形成，α-生育酚在治疗该病方面完全有效，而硒可能部分有效，且该病可能是一种II型肌纤维疾病。文中给出了血浆肌酸磷酸激酶和红细胞谷胱甘肽过氧化物酶活性的数据，以及肝脏终末硒和α-生育酚浓度，并讨论了它们在绵羊断奶期营养性肌病诊断中的作用。
