Department of Surgery, Hamon Center for Therapeutic Oncology Research, NB8.218, UT Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX, 75390-8593, USA.
Division of Surgical Oncology, Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.
Clin Exp Metastasis. 2018 Aug;35(5-6):419-424. doi: 10.1007/s10585-018-9907-9. Epub 2018 May 28.
Ever since it was discovered that endothelial cells line lymphatic vessels, investigators have been working on unraveling the mechanisms that control the growth of this distinctive endothelium and its role in normal physiology and human disease. Recent technological advances have ushered in a new era of "omics" research on the lymphatic system. Research on the genome, transcriptome, proteome, and metabolome of lymphatics has increased our understanding of the biology of the lymphatic vasculature. Here, we introduce the context-lymphatic "systemomics," then briefly review some of the latest advances in research on tumor-associated lymphatic vessels highlighting several "omic" studies that have shed light on mechanisms controlling the growth and function of tumor-associated lymphatic vessels. We conclude by returning, with unanswered questions, to the larger context of cancer and the lymphatic system as a vasculature, circulation, route of entry and transport, and control center of the immune network.
自从发现内皮细胞排列在淋巴管中，研究人员就一直在努力揭示控制这种独特的内皮细胞生长的机制及其在正常生理和人类疾病中的作用。最近的技术进步开创了淋巴系统“组学”研究的新时代。对淋巴管的基因组、转录组、蛋白质组和代谢组的研究增加了我们对淋巴管生物学的理解。在这里，我们介绍了上下文-淋巴“系统组学”，然后简要回顾了肿瘤相关淋巴管研究的一些最新进展，强调了几项“组学”研究，这些研究揭示了控制肿瘤相关淋巴管生长和功能的机制。最后，我们带着未解答的问题回到更大的背景，即癌症和淋巴系统作为一个脉管系统、循环、进入和运输途径以及免疫网络的控制中心。
