在小鼠中，淋巴结转移灶可侵犯局部血管，离开淋巴结，并在远处器官形成转移灶。
Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice.
作者信息
Pereira Ethel R, Kedrin Dmitriy, Seano Giorgio, Gautier Olivia, Meijer Eelco F J, Jones Dennis, Chin Shan-Min, Kitahara Shuji, Bouta Echoe M, Chang Jonathan, Beech Elizabeth, Jeong Han-Sin, Carroll Michael C, Taghian Alphonse G, Padera Timothy P
机构信息
Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital (MGH) Cancer Center, MGH and Harvard Medical School (HMS), Boston, MA 02114, USA.
Division of Gastroenterology, MGH and HMS, Boston, MA 02114, USA.
出版信息
Science. 2018 Mar 23;359(6382):1403-1407. doi: 10.1126/science.aal3622. Epub 2018 Mar 22.
Lymph node metastases in cancer patients are associated with tumor aggressiveness, poorer prognoses, and the recommendation for systemic therapy. Whether cancer cells in lymph nodes can seed distant metastases has been a subject of considerable debate. We studied mice implanted with cancer cells (mammary carcinoma, squamous cell carcinoma, or melanoma) expressing the photoconvertible protein Dendra2. This technology allowed us to selectively photoconvert metastatic cells in the lymph node and trace their fate. We found that a fraction of these cells invaded lymph node blood vessels, entered the blood circulation, and colonized the lung. Thus, in mouse models, lymph node metastases can be a source of cancer cells for distant metastases. Whether this mode of dissemination occurs in cancer patients remains to be determined.
癌症患者的淋巴结转移与肿瘤侵袭性、较差的预后以及全身治疗的推荐有关。淋巴结中的癌细胞是否能够播散至远处形成转移一直是一个备受争议的话题。我们研究了植入表达光转化蛋白Dendra2的癌细胞（乳腺癌、鳞状细胞癌或黑色素瘤）的小鼠。这项技术使我们能够选择性地光转化淋巴结中的转移细胞并追踪它们的去向。我们发现这些细胞中的一部分侵入淋巴结血管，进入血液循环，并在肺部定植。因此，在小鼠模型中，淋巴结转移可能是远处转移癌细胞的一个来源。这种播散方式是否发生在癌症患者中仍有待确定。
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