Li Ruonan, Li Yansen, Su Yongteng, Shen Dan, Dai Pengyuan, Li Chunmei
Jiangsu Provincial Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
Jiangsu Aomai Bio-Tech Company, Nanjing White Horse National Modern Agricultural High-Tech Industrial Park, Nanjing, China.
Anim Sci J. 2018 Aug;89(8):1134-1143. doi: 10.1111/asj.13034. Epub 2018 May 28.
The mycotoxin deoxynivalenol (DON) generally exists in cereals and affects human and animal health. The aim of this study is to analyze the impacts of DON in naturally contaminated feed on piglet growth performance and intestinal hormone secretion in the short term. We randomly divided 5-week-old piglets into four groups: Control, DON 1,000, DON 2,000 and DON 3,000 groups. Piglets received a feed naturally contaminated with DON (approximately 400, 1,000, 2,000 or 3,000 μg/kg) for 21 days. Body weight showed no significant difference following exposure to DON. The balance of anti-oxidation and oxidation was disrupted by DON after 21 days. The concentration of tumor necrosis factor-alpha (TNF-α) and cyclooxgenase-2 (COX-2) significantly increased (p < .001) in all DON-treated groups. Gut anorexigenic hormone secretion of peptide YY (PYY) and cholecystokinin (CCK) had a time- and dose-dependent relationship with DON exposure; however, there was no effect on orexigenic hormone ghrelin secretion. Changes of histomorphology in the jejunum were observed in DON-treated groups, including villi flattening and fusion, and apical necrosis of villi. These results indicated that DON could suppress piglet growth performance and alter gut hormone secretion in the short term.
霉菌毒素脱氧雪腐镰刀菌烯醇（DON）通常存在于谷物中，会影响人类和动物健康。本研究旨在分析天然受污染饲料中的DON对仔猪生长性能和肠道激素分泌的短期影响。我们将5周龄的仔猪随机分为四组：对照组、DON 1000组、DON 2000组和DON 3000组。仔猪接受含天然DON污染的饲料（约400、1000、2000或3000μg/kg），持续21天。接触DON后，体重无显著差异。21天后，DON破坏了抗氧化和氧化的平衡。所有DON处理组中，肿瘤坏死因子-α（TNF-α）和环氧化酶-2（COX-2）的浓度显著增加（p<0.001）。肠道厌食激素肽YY（PYY）和胆囊收缩素（CCK）的分泌与DON暴露呈时间和剂量依赖性关系；然而，对促食欲激素胃饥饿素的分泌没有影响。在DON处理组中观察到空肠组织形态学变化，包括绒毛变平、融合以及绒毛顶端坏死。这些结果表明，DON在短期内可抑制仔猪生长性能并改变肠道激素分泌。
