Department of Animal Nutrition and Feed Science, College of Animal Science and Technology , Huazhong Agricultural University , Wuhan , Hubei 430070 , China.
J Agric Food Chem. 2019 May 1;67(17):4976-4986. doi: 10.1021/acs.jafc.9b01037. Epub 2019 Apr 18.
This study investigated the potential link between gut microbiota and deoxynivalenol (DON)-induced feed refusal. A total of 24 barrows were randomly divided into one of three diets containing 0.61 (control diet), 1.28, or 2.89 mg DON/kg feed for 28 days. Dietary exposure to DON at 2.89 mg/kg significantly decreased the relative abundances of unclassified_f_Lachnospiraceae, Phascolarctobacterium and Ruminococcaceae_UCG-014, whereas it increased Prevotella_9 and norank_f_Prevotellaceae in the cecal digesta. Moreover, the decreased relative abundance of unclassified_f_Lachnospiraceae induced by DON exposure was positively correlated with average daily feed intake. Exposure to DON increased the serum concentrations of glucagon-like peptide-1 and peptide YY but reduced the levels of serum growth hormone and insulin-like growth factor 1. In summary, these findings suggest that chronic dietary exposure to DON induces disturbances of intestinal microbiota. Disturbed appetite-regulating hormones and somatotropic-axis-hormone secretion induced by negative microbial changes could be the potential mechanisms for DON-induced anorexia.
本研究探讨了肠道微生物群与脱氧雪腐镰刀菌烯醇（DON）诱导拒食之间的潜在联系。将 24 头阉公猪随机分为三组，分别饲喂含 0.61（对照饲料）、1.28 或 2.89 mg DON/kg 饲料的日粮 28 天。日粮中 DON 暴露水平为 2.89 mg/kg 时，盲肠内容物中未分类_f_Lachnospiraceae、Phascolarctobacterium 和 Ruminococcaceae_UCG-014 的相对丰度显著降低，而 Prevotella_9 和 norank_f_Prevotellaceae 的相对丰度增加。此外，DON 暴露导致的未分类_f_Lachnospiraceae 相对丰度降低与平均日采食量呈正相关。DON 暴露增加了血清中胰高血糖素样肽-1 和肽 YY 的浓度，但降低了血清生长激素和胰岛素样生长因子 1 的水平。总之，这些发现表明，慢性膳食暴露于 DON 会引起肠道微生物群的紊乱。负向微生物变化引起的食欲调节激素和生长激素轴激素分泌紊乱可能是 DON 诱导厌食的潜在机制。
