Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 120-750, Korea.
Institute of Functional Nano&Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu, 215123, China.
Angew Chem Int Ed Engl. 2018 Sep 3;57(36):11522-11531. doi: 10.1002/anie.201805138. Epub 2018 Aug 7.
Despite its clinical promise, photodynamic therapy (PDT) suffers from a key drawback associated with its oxygen-dependent nature, which limits its effective use against hypoxic tumors. Moreover, both PDT-mediated oxygen consumption and microvascular damage further increase tumor hypoxia and, thus, impede therapeutic outcomes. In recent years, numerous investigations have focused on strategies for overcoming this drawback of PDT. These efforts, which are summarized in this review, have produced many innovative methods to avoid the limits of PDT associated with hypoxia.
尽管光动力疗法（PDT）具有临床应用前景，但它存在一个与氧依赖性相关的关键缺陷，限制了其在乏氧肿瘤中的有效应用。此外，PDT 介导的耗氧量和微血管损伤进一步增加了肿瘤乏氧程度，从而阻碍了治疗效果。近年来，许多研究都集中在克服 PDT 这一缺陷的策略上。本综述总结了这些研究进展，提出了许多避免 PDT 与乏氧相关限制的创新方法。
