Gifford Katherine A, Liu Dandan, Neal Jacquelyn E, Acosta Lealani Mae Y, Bell Susan P, Wiggins Margaret E, Wisniewski Kristi M, Godfrey Mary, Logan Laura A, Hohman Timothy J, Pechman Kimberly R, Libon David J, Blennow Kaj, Zetterberg Henrik, Jefferson Angela L
Vanderbilt University Medical Center, Nashville, TN, USA.
University of Florida, Gainesville, FL, USA.
Assessment. 2020 Sep;27(6):1320-1334. doi: 10.1177/1073191118773870. Epub 2018 May 29.
The Biber Figure Learning Test (BFLT), a visuospatial serial figure learning test, was evaluated for biological correlates and psychometric properties, and normative data were generated. Nondemented individuals ( = 332, 73 ± 7, 41% female) from the Vanderbilt Memory & Aging Project completed a comprehensive neuropsychological protocol. Adjusted regression models related BFLT indices to structural brain magnetic resonance imaging and cerebrospinal fluid (CSF) markers of brain health. Regression-based normative data were generated. Lower BFLT performances (Total Learning, Delayed Recall, Recognition) related to smaller medial temporal lobe volumes and higher CSF tau concentrations but not CSF amyloid. BFLT indices were most strongly correlated with other measures of verbal and nonverbal memory and visuospatial skills. The BFLT provides a comprehensive assessment of all aspects of visuospatial learning and memory and is sensitive to biomarkers of unhealthy brain aging. Enhanced normative data enriches the clinical utility of this visual serial figure learning test for use with older adults.
对Biber图形学习测试（BFLT）进行了评估，该测试是一种视觉空间序列图形学习测试，评估其生物学相关性和心理测量特性，并生成了常模数据。来自范德比尔特记忆与衰老项目的非痴呆个体（n = 332，年龄73±7岁，41%为女性）完成了一项全面的神经心理学测试方案。调整后的回归模型将BFLT指标与脑结构磁共振成像和脑健康的脑脊液（CSF）标志物相关联。生成了基于回归的常模数据。较低的BFLT表现（总学习、延迟回忆、识别）与较小的内侧颞叶体积和较高的脑脊液tau浓度相关，但与脑脊液淀粉样蛋白无关。BFLT指标与言语和非言语记忆以及视觉空间技能的其他测量指标相关性最强。BFLT对视觉空间学习和记忆的各个方面进行了全面评估，并且对不健康脑衰老的生物标志物敏感。增强的常模数据丰富了这种视觉序列图形学习测试在老年人中的临床应用价值。
