Lammintausta R, Kanto J, Mäntylä R
J Int Med Res. 1978;6(5):401-5. doi: 10.1177/030006057800600509.
Acute effects of amiloride (5 mg) (A), hydrochlorthiazide (50 mg) (H) and the combination (50 + 5 mg) (HA) on urinary electrolyte excretion and pH of ten healthy volunteers--taking placebo five times and twice randomly A and HA and once H--were studied during one day. Amiloride showed a natriuretic effect, which in combination was additive to that of hydrochlorthiazide, but the excretion of water did not increase significantly after A. The urinary excretion of potassium decreased with amiloride below normal levels and was at the level of placebo after the combination (HA). There was a striking linear correlation between urinary sodium and potassium with all the drugs, although showing with A a higher potassium retention during high sodium excretion. Urinary pH rose after A and HA during the first 8 hours, but this effect was not seen, however, after H. No significant differences in the effect of the two brands of A (Medamor and Puritrid) on the urinary electrolyte excretion and pH, nor in those of the two brands of HA (Moduretic and Amitrid) were found. Similarly, the plasma concentrations of hydrochlorthiazide, determined gas chromatographically, were equal after Moduretic and Amitrid tablets. The systemic availability of H was faster in the combination of HA than alone. In the AUC value of H, however, there was no significant difference between HA and H tablets.
研究了氨氯吡脒（5毫克）（A）、氢氯噻嗪（50毫克）（H）及其组合（50 + 5毫克）（HA）对10名健康志愿者尿液电解质排泄和pH值的急性影响。在一天的时间里，志愿者服用5次安慰剂，随机服用2次A和HA，1次H。氨氯吡脒显示出利钠作用，与氢氯噻嗪联合使用时具有相加作用，但A使用后水的排泄没有显著增加。氨氯吡脒使钾的尿排泄量降至正常水平以下，联合用药（HA）后恢复到安慰剂水平。所有药物的尿钠和尿钾之间均存在显著的线性相关性，尽管在高钠排泄时A显示出更高的钾潴留。服用A和HA后，最初8小时内尿pH值升高，但服用H后未观察到这种效应。未发现两种品牌的A（Medamor和Puritrid）对尿液电解质排泄和pH值的影响存在显著差异，两种品牌的HA（Moduretic和Amitrid）也无显著差异。同样，通过气相色谱法测定，Moduretic和Amitrid片剂后的氢氯噻嗪血浆浓度相等。HA组合中H的全身可用性比单独使用时更快。然而，在H的AUC值方面，HA片剂和H片剂之间没有显著差异。
