Taylor A, Lallone R
J Nucl Med. 1985 Jan;26(1):77-80.
An abnormal filtration fraction or a significant divergence between a kidney's ability to extract Tc-99m dimercaptosuccinic acid (DMSA) and other function parameters, such as the glomerular filtration rate (GFR) or the effective renal plasma flow (ERPF), could lead to different estimates of relative or absolute renal function, depending on the radiopharmaceutical administered. To evaluate this possible divergence, we measured the relative GFR (I-125 iothalamate), ERPF (I-131 hippurate), and Tc-99m DMSA accumulation in adult male Sprague-Dawley rats with unilateral ureteral obstruction or unilateral ischemia at various times after renal injury. The relative ERPF of the obstructed kidney was significantly greater than the relative GFR at all time periods studied; significant but less dramatic differences were noted comparing DMSA with GFR in obstruction and DMSA and ERPF with GFR in ischemia. In evaluating renal disease, it is important to consider the functional parameter reflected by the administered radiopharmaceutical as well as the underlying disease state.
异常的滤过分数，或者肾脏摄取锝-99m二巯基丁二酸（DMSA）的能力与其他功能参数（如肾小球滤过率（GFR）或有效肾血浆流量（ERPF））之间的显著差异，可能会导致根据所给予的放射性药物对相对或绝对肾功能的不同估计。为了评估这种可能的差异，我们在成年雄性Sprague-Dawley大鼠肾损伤后的不同时间，测量了单侧输尿管梗阻或单侧缺血情况下相对GFR（碘-125泛影酸盐）、ERPF（碘-131马尿酸盐）以及Tc-99m DMSA的蓄积情况。在所有研究时间段内，梗阻侧肾脏的相对ERPF均显著大于相对GFR；在梗阻情况下比较DMSA与GFR，以及在缺血情况下比较DMSA和ERPF与GFR时，均发现了显著但不太明显的差异。在评估肾脏疾病时，重要的是要考虑所给予的放射性药物所反映的功能参数以及潜在的疾病状态。
