禽肉瘤病毒UR2的核苷酸序列及其转化基因与酪氨酸蛋白激酶癌基因家族其他成员的比较。
Nucleotide sequence of avian sarcoma virus UR2 and comparison of its transforming gene with other members of the tyrosine protein kinase oncogene family.
作者信息
Neckameyer W S, Wang L H
出版信息
J Virol. 1985 Mar;53(3):879-84. doi: 10.1128/JVI.53.3.879-884.1985.
Abstract
The genome of avian sarcoma virus UR2 was completely sequenced and found to have a size of 3,165 nucleotides. The UR2-specific transforming sequence, ros, with a length of 1,273 nucleotides, is inserted between the truncated gag gene coding for p19 and the env gene coding for gp37 of the UR2AV helper virus. The deduced amino acid sequence for the UR2 transforming protein P68 gives a molecular weight of 61,113 and shows that it is closely related to the oncogene family coding for tyrosine protein kinases. P68 contains two distinctive hydrophobic regions that are absent in other tyrosine kinases, and it has unique amino acid changes and insertions within the conserved domain of the kinases. These characteristics may modulate the activity and target specificity of P68.
摘要
禽肉瘤病毒UR2的基因组已被完全测序，发现其大小为3165个核苷酸。长度为1273个核苷酸的UR2特异性转化序列ros，插入到UR2AV辅助病毒编码p19的截短gag基因和编码gp37的env基因之间。UR2转化蛋白P68的推导氨基酸序列给出的分子量为61113，表明它与编码酪氨酸蛋白激酶的癌基因家族密切相关。P68包含其他酪氨酸激酶中不存在的两个独特疏水区域，并且在激酶的保守结构域内具有独特的氨基酸变化和插入。这些特征可能会调节P68的活性和靶标特异性。
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