石棉、石英和二氧化钛粉尘对牛红细胞膜影响的自旋标记研究。
A spin label study of the effects of asbestos, quartz, and titanium dioxide dusts on the bovine erythrocyte membrane.
作者信息
Leyko W, Gendek E
出版信息
Br J Ind Med. 1985 Apr;42(4):281-4. doi: 10.1136/oem.42.4.281.
Abstract
The effects of five UICC asbestos samples, titanium dioxide, and quartz on the bovine red cell membrane have been studied in erythrocyte ghosts by the spin labelling technique. Analysis of the electron paramagnetic resonance (EPR) spectra of two sulphydryl reactive spin labels and one fatty acid spin label in red cell ghosts showed modifications in membrane protein after asbestos treatment but no alterations in membrane lipids. In experiments with quartz no membrane changes were noted but titanium dioxide altered the proteins bound with the protein reactive spin label used in the present study. The possible mechanism for these effects is discussed.
摘要
利用自旋标记技术，在红细胞影中研究了五种国际抗癌联盟（UICC）石棉样品、二氧化钛和石英对牛红细胞膜的影响。对红细胞影中两种巯基反应性自旋标记物和一种脂肪酸自旋标记物的电子顺磁共振（EPR）光谱分析表明，石棉处理后膜蛋白发生了改变，但膜脂没有变化。在石英实验中，未观察到膜的变化，但二氧化钛改变了与本研究中使用的蛋白反应性自旋标记物结合的蛋白质。讨论了这些影响的可能机制。
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Br J Ind Med. 1984 Feb;41(1):46-50. doi: 10.1136/oem.41.1.46.
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