Kuchino Y, Nemoto K, Kawai S, Nishimura S
Jpn J Cancer Res. 1985 Feb;76(2):75-8.
Transcription of the c-myc gene in chick embryo fibroblast cells was activated 50- to 100-fold by Rous sarcoma virus (RSV) infection. More than 30-fold activation of c-myc gene transcription was also observed in RSV-transformed rat cells as compared with the control cells. The increased expression of c-myc gene in these cells was not due to gene amplification or gene rearrangement. This striking increase in expression of c-myc gene may be relevant to neoplastic transformation of RSV-infected cells.
劳氏肉瘤病毒（RSV）感染可使鸡胚成纤维细胞中的c-myc基因转录激活50至100倍。与对照细胞相比，在RSV转化的大鼠细胞中也观察到c-myc基因转录激活超过30倍。这些细胞中c-myc基因表达的增加并非由于基因扩增或基因重排。c-myc基因表达的这种显著增加可能与RSV感染细胞的肿瘤转化有关。
