Hung T, Chou Z Y, Zhao T X, Xia S M, Hang C S
Intervirology. 1985;23(2):97-108. doi: 10.1159/000149591.
The morphology and morphogenesis of viruses of hemorrhagic fever with renal syndrome (HFRS) were studied by thin-section electron microscopy. Ten strains of HFRS virus isolated in China and one strain isolated in Korea were compared. The virions varied in size as well as in the shape and character of their inner components. Both intracellular and extracellular ribosome-like, electron-dense, virus-associated granules were seen. A viral antigen layer was often visualized on the surface of HFRS virus-infected cells, as confirmed by immune electron microscopy. Aberrant tailed particles and elongated rod-like particles were seen infrequently. The morphogenesis of HFRS viruses appears to be more complex than that of other members of the family Bunyaviridae. The prototype Hantaan virus shares a common morphology and morphogenesis with the other HFRS viruses studied.
应用超薄切片电子显微镜技术对肾综合征出血热（HFRS）病毒的形态学和形态发生进行了研究。对中国分离的10株HFRS病毒和韩国分离的1株病毒进行了比较。病毒粒子在大小以及内部成分的形状和特征方面存在差异。在细胞内和细胞外均可见到核糖体样、电子致密的病毒相关颗粒。免疫电子显微镜证实，在HFRS病毒感染细胞的表面常可见到病毒抗原层。偶尔可见异常尾状颗粒和细长杆状颗粒。HFRS病毒的形态发生似乎比布尼亚病毒科的其他成员更为复杂。原型汉坦病毒与所研究的其他HFRS病毒具有共同的形态和形态发生特征。
