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猪轮状病毒样病毒(B组轮状病毒):对无菌猪的特性及致病性研究

Porcine rotavirus-like virus (group B rotavirus): characterization and pathogenicity for gnotobiotic pigs.

作者信息

Theil K W, Saif L J, Moorhead P D, Whitmoyer R E

出版信息

J Clin Microbiol. 1985 Mar;21(3):340-5. doi: 10.1128/jcm.21.3.340-345.1985.

DOI:10.1128/jcm.21.3.340-345.1985
PMID:2984243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC271660/
Abstract

A rotavirus-like virus (RVLV) was isolated from a diarrheic pig from an Ohio swine herd. This virus infected villous enterocytes throughout the small intestine of gnotobiotic pigs and induced an acute, transitory diarrhea. Complete virions were rarely observed in the intestinal contents of infected animals; the predominant particle detected by immune electron microscopy was a corelike particle 52 nm in diameter. The genome of the porcine RVLV was composed of 11 discrete segments of double-stranded RNA that produced an electropherotype distinct from the genome electropherotypes of reovirus, rotavirus, and porcine pararotavirus. Porcine RVLV was antigenically unrelated to rotavirus, porcine pararotavirus, or reovirus but was antigenically related to a bovine RVLV.

摘要

从俄亥俄州一个猪群中一头腹泻猪体内分离出一种轮状病毒样病毒(RVLV)。该病毒感染了无菌猪小肠内的绒毛肠上皮细胞,并引发急性短暂性腹泻。在感染动物的肠道内容物中很少观察到完整病毒粒子;免疫电子显微镜检测到的主要颗粒是直径为52纳米的类核心颗粒。猪RVLV的基因组由11个双链RNA离散片段组成,其产生的电泳图谱与呼肠孤病毒、轮状病毒和猪副轮状病毒的基因组电泳图谱不同。猪RVLV与轮状病毒、猪副轮状病毒或呼肠孤病毒在抗原上无相关性,但与一种牛RVLV在抗原上相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f12/271660/6f638af6a82d/jcm00116-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f12/271660/efe5a4b97ffb/jcm00116-0078-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f12/271660/6f638af6a82d/jcm00116-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f12/271660/efe5a4b97ffb/jcm00116-0078-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f12/271660/6f638af6a82d/jcm00116-0080-a.jpg

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