简明综述：前列腺癌干细胞：当前认识。
Concise Review: Prostate Cancer Stem Cells: Current Understanding.
机构信息
Laboratory for Experimental and Translational Research on Radiation Oncology (EXTRO-Lab), Department of Therapeutic Radiology and Oncology, Innsbruck Medical University, Innsbruck, Austria.
Tyrolean Cancer Research Institute, Innsbruck, Austria.
出版信息
Stem Cells. 2018 Oct;36(10):1457-1474. doi: 10.1002/stem.2859. Epub 2018 Aug 27.
Abstract
Prostate cancer (PCa) is heterogeneous, harboring phenotypically diverse cancer cell types. PCa cell heterogeneity is caused by genomic instability that leads to the clonal competition and evolution of the cancer genome and by epigenetic mechanisms that result in subclonal cellular differentiation. The process of tumor cell differentiation is initiated from a population of prostate cancer stem cells (PCSCs) that possess many phenotypic and functional properties of normal stem cells. Since the initial reports on PCSCs in 2005, there has been much effort to elucidate their biological properties, including unique metabolic characteristics. In this Review, we discuss the current methods for PCSC enrichment and analysis, the hallmarks of PCSC metabolism, and the role of PCSCs in tumor progression. Stem Cells 2018;36:1457-1474.
摘要
前列腺癌（PCa）是异质性的，含有表型多样的癌细胞类型。PCa 细胞的异质性是由基因组不稳定性引起的，导致了癌症基因组的克隆竞争和进化，以及表观遗传机制导致的亚克隆细胞分化。肿瘤细胞分化的过程是从一群具有正常干细胞许多表型和功能特性的前列腺癌干细胞（PCSCs）开始的。自 2005 年首次报道 PCSCs 以来，人们一直在努力阐明它们的生物学特性，包括独特的代谢特征。在这篇综述中，我们讨论了 PCSC 富集和分析的当前方法、PCSC 代谢的特征以及 PCSC 在肿瘤进展中的作用。干细胞 2018；36:1457-1474。
相似文献
1
Concise Review: Prostate Cancer Stem Cells: Current Understanding.简明综述：前列腺癌干细胞：当前认识。
Stem Cells. 2018 Oct;36(10):1457-1474. doi: 10.1002/stem.2859. Epub 2018 Aug 27.
2
Therapeutic implications of cancer stem cells in prostate cancer.癌症干细胞在前列腺癌中的治疗意义。
Cancer Biol Med. 2023 Jun 5;20(6):401-20. doi: 10.20892/j.issn.2095-3941.2022.0714.
3
Androgen receptor and prostate cancer stem cells: biological mechanisms and clinical implications.雄激素受体与前列腺癌干细胞：生物学机制及临床意义
Endocr Relat Cancer. 2015 Dec;22(6):T209-20. doi: 10.1530/ERC-15-0217. Epub 2015 Aug 18.
4
New insights into prostate cancer stem cells.前列腺癌干细胞的新见解。
Cell Cycle. 2013 Feb 15;12(4):579-86. doi: 10.4161/cc.23721. Epub 2013 Jan 31.
5
Insights into the Biological Properties of Prostate Cancer Stem Cells: Implications for Cancer Progression and Therapy.前列腺癌干细胞生物学特性的见解：对癌症进展和治疗的启示。
Curr Stem Cell Res Ther. 2025;20(2):166-182. doi: 10.2174/011574888X268997231206112056.
6
SOX2 plays a critical role in EGFR-mediated self-renewal of human prostate cancer stem-like cells.SOX2在表皮生长因子受体（EGFR）介导的人前列腺癌干细胞样细胞自我更新过程中发挥关键作用。
Cell Signal. 2013 Dec;25(12):2734-42. doi: 10.1016/j.cellsig.2013.08.041. Epub 2013 Sep 13.
7
Systematic dissection of phenotypic, functional, and tumorigenic heterogeneity of human prostate cancer cells.对人类前列腺癌细胞的表型、功能和致瘤异质性进行系统剖析。
Oncotarget. 2015 Sep 15;6(27):23959-86. doi: 10.18632/oncotarget.4260.
8
Role of EZH2 in the growth of prostate cancer stem cells isolated from LNCaP cells.EZH2在从LNCaP细胞分离出的前列腺癌干细胞生长中的作用。
Int J Mol Sci. 2013 Jun 5;14(6):11981-93. doi: 10.3390/ijms140611981.
9
Embryonic microenvironment suppresses YY1 and YY1-related genes in prostate cancer stem cells.胚胎微环境抑制前列腺癌细胞中的 YY1 和 YY1 相关基因。
Pathol Res Pract. 2024 Aug;260:155467. doi: 10.1016/j.prp.2024.155467. Epub 2024 Jul 15.
10
Prostate cancer stem-like cells proliferate slowly and resist etoposide-induced cytotoxicity via enhancing DNA damage response.前列腺癌干细胞样细胞增殖缓慢，并通过增强DNA损伤反应来抵抗依托泊苷诱导的细胞毒性。
Exp Cell Res. 2014 Oct 15;328(1):132-142. doi: 10.1016/j.yexcr.2014.08.016. Epub 2014 Aug 20.
引用本文的文献
1
Unlocking the Role of OCT4 in Cancer Lineage Plasticity: A Cross-Cancer Perspective with an Emphasis on Prostate Cancer.揭示OCT4在癌症谱系可塑性中的作用：跨癌症视角，重点关注前列腺癌。
Biomedicines. 2025 Jul 4;13(7):1642. doi: 10.3390/biomedicines13071642.
2
LINC00908 Inactivates Wnt/β-Catenin Signaling Pathway to Inhibit Prostate Cancer Cell Stemness via Upregulating GSK3B and FBXW2.LINC00908通过上调GSK3B和FBXW2使Wnt/β-连环蛋白信号通路失活，从而抑制前列腺癌细胞干性。
Cancer Med. 2025 May;14(9):e70887. doi: 10.1002/cam4.70887.
3
Methylation Levels in Androgen-Deprived Prostate Cancer: A Putative Epigenetic Modulator of Tumor Progression.雄激素剥夺性前列腺癌中的甲基化水平：肿瘤进展的一种潜在表观遗传调节因子
Int J Mol Sci. 2025 Mar 11;26(6):2516. doi: 10.3390/ijms26062516.
4
Prostate cancer-specific proinflammatory cytokines and chemokines impact on cancer stem cell development, lineage plasticity and heterogeneity in an Ancestral/racially diverse population: review.前列腺癌特异性促炎细胞因子和趋化因子对祖先/种族多样化人群中癌症干细胞的发育、谱系可塑性和异质性的影响：综述
Cancer Metastasis Rev. 2025 Mar 19;44(2):41. doi: 10.1007/s10555-025-10259-1.
5
oncology: a mechanistic multiscale model of clinical prostate cancer response to external radiation therapy as the core of a digital (virtual) twin. Sensitivity analysis and a clinical adaptation approach.肿瘤学：临床前列腺癌对外照射治疗反应的多尺度机制模型作为数字（虚拟）孪生的核心。敏感性分析和临床适应方法。
Front Physiol. 2025 Feb 24;16:1434739. doi: 10.3389/fphys.2025.1434739. eCollection 2025.
6
Clinical significance of stratifying prostate cancer patients through specific circulating genes.通过特定循环基因对前列腺癌患者进行分层的临床意义。
Mol Oncol. 2025 May;19(5):1310-1331. doi: 10.1002/1878-0261.13805. Epub 2025 Jan 22.
7
Iroquois homeobox 4 (IRX4) derived micropeptide promotes prostate cancer progression and chemoresistance through Wnt signalling dysregulation.易洛魁同源盒4（IRX4）衍生的微小肽通过Wnt信号失调促进前列腺癌进展和化疗耐药。
Commun Med (Lond). 2024 Nov 1;4(1):224. doi: 10.1038/s43856-024-00613-9.
8
Human intermediate prostate cancer stem cells contribute to the initiation and development of prostate adenocarcinoma.人前列腺中端癌细胞促进前列腺腺癌的发生和发展。
Stem Cell Res Ther. 2024 Sep 11;15(1):296. doi: 10.1186/s13287-024-03917-8.
9
Current advancements in nanotechnology for stem cells.用于干细胞的纳米技术的当前进展。
Int J Surg. 2024 Dec 1;110(12):7456-7476. doi: 10.1097/JS9.0000000000002082.
10
Glutamine Metabolism and Prostate Cancer.谷氨酰胺代谢与前列腺癌
Cancers (Basel). 2024 Aug 18;16(16):2871. doi: 10.3390/cancers16162871.
本文引用的文献
1
Androgen receptor splice variants bind to constitutively open chromatin and promote abiraterone-resistant growth of prostate cancer.雄激素受体剪接变异体与持续开放的染色质结合，并促进前列腺癌对阿比特龙的耐药性生长。
Nucleic Acids Res. 2018 Feb 28;46(4):1895-1911. doi: 10.1093/nar/gkx1306.
2
Targeting aggressive prostate cancer-associated CD44v6 using phage display selected peptides.利用噬菌体展示筛选的肽靶向侵袭性前列腺癌相关的CD44v6
Oncotarget. 2017 Sep 30;8(49):86747-86768. doi: 10.18632/oncotarget.21421. eCollection 2017 Oct 17.
3
Multiplex Gene Expression Profiling of In Vivo Isolated Circulating Tumor Cells in High-Risk Prostate Cancer Patients.高危前列腺癌患者体内分离的循环肿瘤细胞的多重基因表达谱分析。
Clin Chem. 2018 Feb;64(2):297-306. doi: 10.1373/clinchem.2017.275503. Epub 2017 Nov 9.
4
Androgen receptor amplification is concordant between circulating tumor cells and biopsies from men undergoing treatment for metastatic castration resistant prostate cancer.在接受转移性去势抵抗性前列腺癌治疗的男性中，循环肿瘤细胞与活检组织之间的雄激素受体扩增情况是一致的。
Oncotarget. 2017 Mar 13;8(42):71447-71455. doi: 10.18632/oncotarget.16169. eCollection 2017 Sep 22.
5
Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling.雄激素受体信号通路非依赖性前列腺癌通过成纤维细胞生长因子信号得以维持。
Cancer Cell. 2017 Oct 9;32(4):474-489.e6. doi: 10.1016/j.ccell.2017.09.003.
6
Identification and Isolation of Cancer Stem Cells Using NANOG-EGFP Reporter System.利用NANOG-EGFP报告系统鉴定和分离癌症干细胞
Methods Mol Biol. 2018;1692:139-148. doi: 10.1007/978-1-4939-7401-6_13.
7
The Role and Mechanism of Epithelial-to-Mesenchymal Transition in Prostate Cancer Progression.上皮-间质转化在前列腺癌进展中的作用和机制。
Int J Mol Sci. 2017 Sep 30;18(10):2079. doi: 10.3390/ijms18102079.
8
Mitochondrial mutations drive prostate cancer aggression.线粒体突变促使前列腺癌侵袭。
Nat Commun. 2017 Sep 22;8(1):656. doi: 10.1038/s41467-017-00377-y.
9
Improving circulating tumor cells enumeration and characterization to predict outcome in first line chemotherapy mCRPC patients.改善循环肿瘤细胞计数与特征分析以预测一线化疗的转移性去势抵抗性前列腺癌（mCRPC）患者的预后。
Oncotarget. 2017 May 19;8(33):54708-54721. doi: 10.18632/oncotarget.18025. eCollection 2017 Aug 15.
10
WNT signalling in prostate cancer.WNT 信号通路在前列腺癌中的作用。
Nat Rev Urol. 2017 Nov;14(11):683-696. doi: 10.1038/nrurol.2017.144. Epub 2017 Sep 12.
Zotero 插件