Laboratory for Experimental and Translational Research on Radiation Oncology (EXTRO-Lab), Department of Therapeutic Radiology and Oncology, Innsbruck Medical University, Innsbruck, Austria.
Tyrolean Cancer Research Institute, Innsbruck, Austria.
Stem Cells. 2018 Oct;36(10):1457-1474. doi: 10.1002/stem.2859. Epub 2018 Aug 27.
Prostate cancer (PCa) is heterogeneous, harboring phenotypically diverse cancer cell types. PCa cell heterogeneity is caused by genomic instability that leads to the clonal competition and evolution of the cancer genome and by epigenetic mechanisms that result in subclonal cellular differentiation. The process of tumor cell differentiation is initiated from a population of prostate cancer stem cells (PCSCs) that possess many phenotypic and functional properties of normal stem cells. Since the initial reports on PCSCs in 2005, there has been much effort to elucidate their biological properties, including unique metabolic characteristics. In this Review, we discuss the current methods for PCSC enrichment and analysis, the hallmarks of PCSC metabolism, and the role of PCSCs in tumor progression. Stem Cells 2018;36:1457-1474.
前列腺癌（PCa）是异质性的，含有表型多样的癌细胞类型。PCa 细胞的异质性是由基因组不稳定性引起的，导致了癌症基因组的克隆竞争和进化，以及表观遗传机制导致的亚克隆细胞分化。肿瘤细胞分化的过程是从一群具有正常干细胞许多表型和功能特性的前列腺癌干细胞（PCSCs）开始的。自 2005 年首次报道 PCSCs 以来，人们一直在努力阐明它们的生物学特性，包括独特的代谢特征。在这篇综述中，我们讨论了 PCSC 富集和分析的当前方法、PCSC 代谢的特征以及 PCSC 在肿瘤进展中的作用。干细胞 2018；36:1457-1474。
