1 School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China.
2 Eone Diagnomics Genome Center, Incheon, Republic of Korea.
Am J Alzheimers Dis Other Demen. 2018 Sep;33(6):373-384. doi: 10.1177/1533317518778513. Epub 2018 May 30.
Mild cognitive impairment (MCI) is considered to be the clinical transition stage between patients with cognitively intact geriatrics and Alzheimer's disease (AD). When observed longitudinally, however, a certain proportion of patients with MCI are expected to revert to a cognitively intact state (MCI_R) while others either remain in the MCI state (MCI_S) or deteriorate into AD (MCI_P). It is worthwhile to investigate the divergence in the brain activities of these MCI groups with different post hoc labels.
In this study, we employed the regional homogeneity (ReHo) measure to explore the characteristics of local brain activity in these MCI groups.
Compared to age-matched normal controls, our results exhibited that (1) in MCI_R group, ReHo index showed an increase in the left insula and a decrease in the left superior temporal gyrus; (2) in MCI_S group, ReHo index increased in the left orbital part of the inferior frontal gyrus (IFG_orb) and decreased in the left inferior parietal lobe; and (3) in MCI_P group, ReHo index elevated in the left IFG_orb and decreased in the left putamen.
The distinct ReHo changes in the individual MCI groups indicated a potential evidence for differentially active interventions for a specific patient with MCI.
轻度认知障碍（MCI）被认为是认知正常老年人和阿尔茨海默病（AD）患者之间的临床过渡阶段。然而，当进行纵向观察时，预计一定比例的 MCI 患者会恢复到认知正常状态（MCI_R），而其他患者则保持 MCI 状态（MCI_S）或恶化到 AD（MCI_P）。值得研究这些具有不同事后标签的 MCI 组的脑活动差异。
在这项研究中，我们采用局部一致性（ReHo）测量来探索这些 MCI 组局部脑活动的特征。
与年龄匹配的正常对照组相比，我们的结果显示：（1）在 MCI_R 组中，ReHo 指数在左侧脑岛增加，在左侧颞上回减少；（2）在 MCI_S 组中，ReHo 指数在左侧额下回眶部（IFG_orb）增加，在左侧顶下小叶减少；（3）在 MCI_P 组中，ReHo 指数在左侧 IFG_orb 增加，在左侧壳核减少。
个体 MCI 组中明显的 ReHo 变化表明，对于特定的 MCI 患者，可能需要进行有针对性的干预。
