Sun Jing, Xu Yimeng, Zhu Bowu, Gao Gui, Ren Junfang, Wang Honggang, Lin Yongsheng, Cao Baocheng
School of Stomatology, Lanzhou University.
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences.
Dent Mater J. 2019 Feb 8;38(1):41-51. doi: 10.4012/dmj.2018-001. Epub 2018 May 31.
In this study, we evaluate the effect of co-doping with TiO2 nanoparticles and sisal cellulose nanocrystals (CNCs) on the physical and biological properties of a conventional glass-ionomer cement (GIC). Test samples were characterized by scanning electron microscopy, and Fourier-transform infrared spectroscopy, and subjected to mechanical tests to evaluate the mechanical performances. Antimicrobial activity was evaluated against Candida albicans, and cytotoxicity experiments were conducted using L-929 cells. Unmodified GIC served as a control. Compared with the control group, the co-doped group demonstrated an increased compressive strength of 18.9%, an increased shear bond strength of 51%, the dissolution decreased by 18.3%, the volume wear rate was reduced by 5%. The antifungal effect against C. albicans was increased by 22%. In cytotoxicity experiments, the co-doped group had a slightly negative effect on the viability of L-929 cells.
在本研究中，我们评估了二氧化钛纳米颗粒与剑麻纤维素纳米晶体（CNCs）共掺杂对传统玻璃离子水门汀（GIC）物理和生物学性能的影响。通过扫描电子显微镜和傅里叶变换红外光谱对测试样品进行表征，并进行力学测试以评估力学性能。评估了对白色念珠菌的抗菌活性，并使用L-929细胞进行了细胞毒性实验。未改性的GIC用作对照。与对照组相比，共掺杂组的抗压强度提高了18.9%，剪切粘结强度提高了51%，溶解率降低了18.3%，体积磨损率降低了5%。对白色念珠菌的抗真菌效果提高了22%。在细胞毒性实验中，共掺杂组对L-929细胞的活力有轻微负面影响。
