Biomedical and Cell Therapy Research Laboratory, Department of Biomedical Engineering, McGill University, 3775 University Street, Room 322, Montreal, QC, H3A2B4, Canada.
Sci Rep. 2018 May 30;8(1):8362. doi: 10.1038/s41598-018-25382-z.
Aging and chronic disease development are multifactorial processes involving the cumulative effects of metabolic distress, inflammation, oxidative stress and mitochondrial dynamics. Recently, variations in the gut microbiota have been associated with age-related phenotypes and probiotics have shown promise in managing chronic disease progression. In this study, novel probiotic and synbiotic formulations are shown to combinatorially extend longevity in male Drosophila melanogaster through mechanisms of gut-brain-axis communication with implications in chronic disease management. Both the probiotic and synbiotic formulations rescued markers of metabolic stress by managing insulin resistance and energy regulatory pathways. Both formulations also ameliorated elevations in inflammation, oxidative stress and the loss of mitochondrial complex integrity. In almost all the measured pathways, the synbiotic formulation has a more robust impact than its individual components insinuating its combinatorial effect. The concomitant action of the gut microbiota on each of the key risk factors of aging and makes it a powerful therapeutic tool against neurodegeneration, diabetes, obesity, cardiovascular disease and other age-related chronic diseases.
衰老和慢性疾病的发展是多因素的过程，涉及代谢失调、炎症、氧化应激和线粒体动力学的累积效应。最近，肠道微生物群的变异与与年龄相关的表型有关，益生菌在管理慢性疾病进展方面显示出前景。在这项研究中，新型益生菌和合生制剂通过肠道-大脑轴通讯的机制，以组合的方式延长雄性果蝇的寿命，这对慢性疾病的管理有影响。益生菌和合生制剂都通过管理胰岛素抵抗和能量调节途径来挽救代谢应激的标志物。这两种制剂还改善了炎症、氧化应激和线粒体复合物完整性的丧失。在几乎所有测量的途径中，合生制剂比其单个成分更有影响力，暗示了其组合效应。肠道微生物群对衰老的每个关键风险因素的共同作用使其成为对抗神经退行性疾病、糖尿病、肥胖、心血管疾病和其他与年龄相关的慢性疾病的有力治疗工具。
