Prakoso Yos Adi, Setiyo Rini Chylen, Wirjaatmadja Roeswandono
Integrated Laboratory, Faculty of Health, University of Muhammadiyah Sidoarjo, East Java, Indonesia.
Faculty of Veterinary Medicine, University of Wijaya Kusuma Surabaya, East Java, Indonesia.
Adv Pharmacol Sci. 2018 Apr 19;2018:4670569. doi: 10.1155/2018/4670569. eCollection 2018.
The tropical area has a lot of herbal medicines such as (AV), (AC), and (SM). All the three have a unique potential effect as an antibacterial and wound-healing promoter. The aim of this study is to explore the role of AV, AC, and SM on the skin wound infected with methicillin-resistant (MRSA). Forty-five adult female Sprague Dawley rats weighing 250-300 grams were divided into 5 groups. All the groups were exposed to two round full-thickness punch biopsy and infected with MRSA. The group C was the control group/untreated; group BC was treated with base cream/without extract; group AV was treated with 75% AV cream; group AC was treated with 75% AC cream, and group SM was treated with 75% SM cream. The wounds were observed on days 5, 10, and 15. The healing of skin wounds was measured by a percentage of closure, skin tensile strength, and histopathology. The result showed that AV, AC, and SM have a similar potential effect on healing in the wound that was infected with MRSA compared to the groups C and BC ( < 0.05). It shows that all the three herbal formulations can be used as the alternative therapy to the wound infected with MRSA.
热带地区有许多草药，如（AV）、（AC）和（SM）。这三种草药都具有独特的抗菌和促进伤口愈合的潜在作用。本研究的目的是探讨AV、AC和SM对耐甲氧西林金黄色葡萄球菌（MRSA）感染的皮肤伤口的作用。将45只体重250 - 300克的成年雌性Sprague Dawley大鼠分为5组。所有组均接受两次全层环形打孔活检并感染MRSA。C组为对照组/未治疗组；BC组用基础乳膏治疗/不含提取物；AV组用75%的AV乳膏治疗；AC组用75%的AC乳膏治疗，SM组用75%的SM乳膏治疗。在第5天、第10天和第15天观察伤口。通过伤口闭合百分比、皮肤抗张强度和组织病理学来测量皮肤伤口的愈合情况。结果表明，与C组和BC组相比，AV、AC和SM对MRSA感染伤口的愈合具有相似的潜在作用（<0.05）。这表明这三种草药制剂均可作为MRSA感染伤口的替代治疗方法。
