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塔科林，一种从茎中提取的物质，通过调节肿瘤坏死因子α、转化生长因子β和基质金属蛋白酶2的表达来促进伤口愈合。

Tacorin, an extract from stem, stimulates wound healing by modulating the expression of tumor necrosis factor α, transforming growth factor β and matrix metalloproteinase 2.

作者信息

Rahayu Puji, Agustina Lia, Tjandrawinata Raymond R

机构信息

Biopharmaceutical Technology Division Dexa Laboratories of Biomolecular Sciences PT Dexa Medica Cikarang Indonesia.

出版信息

FEBS Open Bio. 2017 Jun 9;7(7):1017-1025. doi: 10.1002/2211-5463.12241. eCollection 2017 Jul.

DOI:10.1002/2211-5463.12241
PMID:28680814
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5494315/
Abstract

Wound healing is a complex biological process that involves integration of hemostasis, inflammation, proliferation and tissue remodeling. An extract of pineapple () stem demonstrates several therapeutics properties, including acceleration of wound healing. Tacorin is a water crude extract derived from the stem of with high protein content. The effect of tacorin on wound healing was examined using rats with an induced injury. Wound closure was faster with tacorin treatment than in the untreated group. An study was conducted on mammalian cells (3T3-L1) to observe the effect of tacorin on cell proliferation. Tacorin was first heated to inactivate its proteolytic activity. It increased the viability of 3T3-L1 cells in a dose-dependent manner. Excessive inflammation was suppressed by tacorin as shown by decreased tumor necrosis factor α expression. Treatment with tacorin increased the expression of transforming growth factor β, a major player in tissue remodeling. Moreover, tacorin also reduced the expression of MMP-2 to accelerate the recovery of the wound. Taken together, tacorin is able to accelerate the wound-healing process by increasing cell proliferation, suppressing inflammation and accelerating tissue remodeling.

摘要

伤口愈合是一个复杂的生物学过程，涉及止血、炎症、增殖和组织重塑的整合。菠萝（）茎提取物具有多种治疗特性，包括加速伤口愈合。塔科林是一种从含高蛋白的茎中提取的水粗提物。使用诱导损伤的大鼠研究了塔科林对伤口愈合的影响。与未治疗组相比，塔科林治疗组的伤口闭合更快。对哺乳动物细胞（3T3-L1）进行了一项研究，以观察塔科林对细胞增殖的影响。首先将塔科林加热以使其蛋白水解活性失活。它以剂量依赖的方式增加了3T3-L1细胞的活力。如肿瘤坏死因子α表达降低所示，塔科林抑制了过度炎症。塔科林治疗增加了转化生长因子β的表达，转化生长因子β是组织重塑中的主要参与者。此外，塔科林还降低了MMP-2的表达以加速伤口恢复。综上所述，塔科林能够通过增加细胞增殖、抑制炎症和加速组织重塑来加速伤口愈合过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df8/5494315/6b3ba863393e/FEB4-7-1017-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df8/5494315/098c2c8e2ce0/FEB4-7-1017-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df8/5494315/597114a823c7/FEB4-7-1017-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df8/5494315/6999ebe7ff63/FEB4-7-1017-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df8/5494315/59428151160d/FEB4-7-1017-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df8/5494315/d90f193116ef/FEB4-7-1017-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df8/5494315/ef6e8f92aac5/FEB4-7-1017-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df8/5494315/6f166859d9d8/FEB4-7-1017-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df8/5494315/c0c7d801f22e/FEB4-7-1017-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df8/5494315/6b3ba863393e/FEB4-7-1017-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df8/5494315/098c2c8e2ce0/FEB4-7-1017-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df8/5494315/597114a823c7/FEB4-7-1017-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df8/5494315/6999ebe7ff63/FEB4-7-1017-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df8/5494315/59428151160d/FEB4-7-1017-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df8/5494315/d90f193116ef/FEB4-7-1017-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df8/5494315/ef6e8f92aac5/FEB4-7-1017-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df8/5494315/6f166859d9d8/FEB4-7-1017-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df8/5494315/c0c7d801f22e/FEB4-7-1017-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df8/5494315/6b3ba863393e/FEB4-7-1017-g009.jpg

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