González Carlos, Forner Leopoldo, Llena Carmen, Lozano Adrián
DDS, Department of Stomatology Universitat de València.
MD, DDS, PhD, Department of Stomatology Universitat de València.
J Clin Exp Dent. 2018 May 1;10(5):e458-e461. doi: 10.4317/jced.54732. eCollection 2018 May.
Chlorhexidine is an irrigant solution widely used in root canal treatment because of its good antimicrobial properties. However, its mixture with sodium hypochlorite results in the appearance of substance called p-chloroaniline, a cytotoxic substance. This is also found when chlorhexidine is heated. The use of passive ultrasonic irrigation is related to an irrigant thermal increase, which can cause the appearance of p-chloroaniline. Thus, the objective is to establish the influence of ultrasonic and sonic activation, with the use of different intensities, upon the temperature of chlorhexidine gluconate (CHX).
The following groups were established: control (without activation), ultrasonic activation and sonic activation. A 0.5-ml volume of CHX was placed in an Eppendorf tube in a thermo-static bath at 37ºC. Both methods resulted in immediate CHX activation. The temperature was recorded every 30 seconds between 60 and 180 seconds. The statistical analysis was performed based on the Mann-Whitney U-test.
Both groups subjected to activation showed higher temperatures than the control group, and increased activation intensity was associated to greater temperature increments in both activated groups.
Both ultrasonic and sonic activation are correlated to temperature increase in CHX. Chlorhexidine, p-choroaniline, PUI, sonic irrigation, temperature.
洗必泰是一种因其良好的抗菌性能而广泛用于根管治疗的冲洗液。然而，它与次氯酸钠混合会产生一种名为对氯苯胺的物质，这是一种细胞毒性物质。洗必泰加热时也会出现这种物质。使用被动超声冲洗与冲洗液温度升高有关，这可能会导致对氯苯胺的出现。因此，目的是确定使用不同强度的超声和声波激活对葡萄糖酸氯己定（CHX）温度的影响。
设立以下几组：对照组（未激活）、超声激活组和声波激活组。将0.5毫升的CHX置于37℃恒温浴中的Eppendorf管中。两种方法均导致CHX立即激活。在60至180秒之间每隔30秒记录一次温度。基于曼-惠特尼U检验进行统计分析。
两组激活组的温度均高于对照组，且激活强度增加与两组激活组中更大的温度升高相关。
超声和声波激活均与CHX温度升高相关。氯己定、对氯苯胺、被动超声冲洗、声波冲洗、温度。
