Department of Chemistry, College of Natural Sciences and Mathematics, University of Houston, Houston, TX 77204, USA.
Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA.
Molecules. 2021 Jul 27;26(15):4521. doi: 10.3390/molecules26154521.
Aporphines, a major group of aporphinoid alkaloids, exhibit interesting and diverse pharmacological activities. A set of dimeric aporphines with an aryloxy group at C8, C9, and C11 have been isolated from six genera and shown to elicit various biological activities such as antitumor, antimalarial, antimicrobial, antiplatelet aggregation, antifibrotic, immunosuppressive, and vasorelaxant properties. In this review, the nomenclature, chemical structures, botanical sources, pharmacological activities, and synthetic approaches of this set of dimeric alkaloids are presented.
阿朴啡类生物碱是阿朴啡类生物碱中的一个主要类别，具有有趣多样的药理学活性。一组在 C8、C9 和 C11 位具有芳氧基的二聚体阿朴啡类生物碱已从六个属中分离出来，并显示出多种生物活性，如抗肿瘤、抗疟、抗微生物、抗血小板聚集、抗纤维化、免疫抑制和血管舒张作用。在这篇综述中，介绍了这组二聚体生物碱的命名、化学结构、植物来源、药理学活性和合成方法。
