State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; Guizhou University of Traditional Chinese Medicine, Guiyang 550025, PR China.
Fitoterapia. 2020 Jan;140:104445. doi: 10.1016/j.fitote.2019.104445. Epub 2019 Nov 30.
Thallactones A (1) and B (2), enantiomeric aporphine alkaloids with rare cleaved rings A and B, as well as thaliglucine N-oxide (3) and their biosynthetically related precursor, northalphenine (4), were isolated from the whole plant of Thalictrum wangii. Their structures with absolute configurations were elucidated by spectral techniques and electronic circular dichroism (ECD). Moreover, compounds 1, 3, and northalphenine inhibited concanavalin A (Con A)-stimulated proliferation of mice splenocyte significantly in a dose-dependent manner.
从獐牙菜属植物王獐牙菜中分离得到了具有罕见裂解环 A 和 B 的对映体阿朴啡生物碱獐牙菜苦酮 A（1）和 B（2），以及獐牙菜苦酮 N-氧化物（3）及其生物合成相关前体化合物北美黄连碱（4）。通过光谱技术和电子圆二色谱（ECD）确定了它们的结构和绝对构型。此外，化合物 1、3 和北美黄连碱以剂量依赖的方式显著抑制刀豆蛋白 A（Con A）刺激的小鼠脾细胞增殖。
