College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu, 610041, China.
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.
Colloids Surf B Biointerfaces. 2018 Sep 1;169:478-485. doi: 10.1016/j.colsurfb.2018.05.057. Epub 2018 May 26.
As the basic component of natural bone in the human body, hydroxyapatite is widely used in orthopedic, dental, and bone implants, especially as a surface coating to improve osteoconductivity and osseointeration of materials. Several methods have been used for hydroxyapatite coating, including plasma spraying, laser pulse deposition, and electrophoretic and electrochemical deposition. However, these methods require expensive instruments and involve complex operations. Thus, it is highly desirable to develop a feasible, simple, cheap, and universal method to prepare hydroxyapatite coatings. In this work, we develop a method for hydroxyapatite coating on various materials by a phytic acid-metal complex multilayer. The abundant phosphate moieties on phytic acid not only work for chemical modification of a wide range of materials but also for further the formation of hydroxyapatite. The formed crystals improve the biocompatibility and osteogenic ability of MG63 cells. This method is simple, cheap, and novel, and can be utilized in biomedical applications such as orthopedic, dental, and bone implants.
作为人体天然骨的基本组成部分，羟基磷灰石被广泛应用于骨科、牙科和骨植入物，特别是作为表面涂层，以提高材料的骨传导性和骨整合性。已经有几种方法用于羟基磷灰石涂层，包括等离子喷涂、激光脉冲沉积以及电泳和电化学沉积。然而，这些方法需要昂贵的仪器并且涉及复杂的操作。因此，开发一种可行、简单、廉价且通用的方法来制备羟基磷灰石涂层是非常需要的。在这项工作中，我们通过植酸-金属配合物多层膜开发了一种在各种材料上涂覆羟基磷灰石的方法。植酸上丰富的磷酸基团不仅可以用于对各种材料进行化学修饰，还可以进一步形成羟基磷灰石。所形成的晶体提高了 MG63 细胞的生物相容性和成骨能力。这种方法简单、廉价且新颖，可用于骨科、牙科和骨植入物等生物医学应用。
