Kaur Harleen, Grover Vishakha, Malhotra Ranjan, Gupta Mili
Baba Jaswant Singh Dental College, Ludhiana, India.
Department of Periodontology, H.S. Judge Institute of Dental Sciences, P.U., Chandigarh, India.
Infect Disord Drug Targets. 2019;19(2):171-178. doi: 10.2174/1871526518666180601073422.
Successful management of periodontitis requires treatment strategy that integrates therapies addressing both pathogen and host aspects of disease etiology. To evaluate sub gingivally applied curcumin gel in treatment of chronic periodontitis based on clinical and biochemical parameters.
MATERIALS & METHODS: A randomized, double blind, parallel-group trial was carried out on 30 patients suffering from chronic generalized periodontitis with probing pocket depth≥5mm on at least 4 sites who were then randomly allocated to two groups. Control group was treated with Scaling and Root Planing (SRP) alone while experimental group was treated with SRP followed by subgingival application of curcumin gel. Saliva collection was done and the clinical parameters were recorded at baseline and follow up periods. Saliva analysis for IL-1β was done by ELISA. The statistical differences for the intra-group and intergroup measurements were analyzed by using Mann Whitney test. Spearman's rank correlation coefficient was used to examine the relationship between Interleukin - 1β and clinical parameters.
Study elucidated mild adjunctive benefit of curcumin gel in reduction of gingival inflammation for a limited period of time. Though improvement in other clinical parameters was also greater in subjects treated with curcumin gel, results were not statistically different from those treated with SRP alone. None of the subjects who received curcumin gel experienced any adverse effect.
Within limitations, it can be concluded that single application of curcumin (turmeric) gel has limited added benefit over scaling and root planing in treatment of chronic periodontitis.
成功治疗牙周炎需要一种综合治疗策略，该策略整合了针对疾病病因中病原体和宿主方面的疗法。基于临床和生化参数评估龈下应用姜黄素凝胶治疗慢性牙周炎的效果。
对30例患有慢性广泛性牙周炎且至少4个部位探诊袋深度≥5mm的患者进行了一项随机、双盲、平行组试验，然后将他们随机分为两组。对照组仅接受龈上洁治和根面平整（SRP）治疗，而实验组在接受SRP治疗后再进行龈下应用姜黄素凝胶治疗。在基线期和随访期收集唾液并记录临床参数。通过酶联免疫吸附测定法（ELISA）对唾液中的白细胞介素-1β（IL-1β）进行分析。采用Mann Whitney检验分析组内和组间测量的统计学差异。使用Spearman等级相关系数检验白细胞介素-1β与临床参数之间的关系。
研究表明姜黄素凝胶在短期内减轻牙龈炎症方面有轻微的辅助益处。尽管接受姜黄素凝胶治疗的受试者在其他临床参数方面的改善也更大，但结果与仅接受SRP治疗的受试者相比无统计学差异。接受姜黄素凝胶治疗的受试者均未出现任何不良反应。
在一定限制范围内，可以得出结论，在慢性牙周炎的治疗中，单次应用姜黄素（姜黄）凝胶相较于龈上洁治和根面平整仅有有限的额外益处。
