Oral Medicine, Periodontology, Diagnosis, and Oral Radiology Department, Faculty of Dentistry, Mansoura University, Mansoura, 35516, Egypt.
Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
BMC Oral Health. 2023 Nov 19;23(1):883. doi: 10.1186/s12903-023-03512-y.
To evaluate the effect of curcumin gel combined with scaling and root planing (SRP) on salivary procalcitonin in periodontitis treatment.
seventy patients were selected from the Department of Oral Medicine and Periodontology, Faculty of Dentistry, Mansoura University, and sixteen patients were excluded. Patients in groups II and III included stage II grade A periodontitis. The participants were classified into three groups: group I as a negative control group (individuals with healthy gingiva), group II (SRP) were treated with SRP, and group III (curcumin gel) which was applied weekly for four weeks after SRP. Clinical indices (plaque index (PI), gingival index (GI), clinical attachment level (CAL), and probing depth (PD)) and saliva samples for procalcitonin (PCT) assessment using an enzyme-linked immunosorbent assay (ELISA) test were collected and measured at both baselines and after six weeks.
This randomized controlled clinical trial registered on ClinicalTrials.gov (NCT05667376) and first posted at 28/12/2022 included Fifty-four patients (20 male; 34 female). Regarding the age and sex distribution, there was no statistically significant difference between the three studied groups (p > 0.05). There was no significant statistical difference regarding PI, GI, PPD, and CAL between group II and group III at baseline p (> 0.05). However, there was a significant statistical difference regarding the clinical parameters at baseline of both group II and group III as compared to group I (p ≤ 0.05). At six weeks after treatment, group III showed greater improvement in the PI, PD, and CAL as opposed to group II (p ≤ 0.05). Regarding PCT values, at baseline, there wasn't a statistically significant difference between group II and group III (p > 0.05). However, there was a significant statistical difference between group II, group III, and group I (p ≤ 0.05). At six weeks after treatment, there was a statistically significant decrease in PCT levels of both group II and III (p ≤ 0.05).
The application of curcumin gel was found to have a significant effect on all clinical indices as opposed to SRP.
评估姜黄素凝胶联合洁治和根面平整术（SRP）对牙周炎治疗中唾液降钙素原的影响。
从曼苏拉大学牙科学院口腔医学和牙周病学系选择了 70 名患者，其中 16 名患者被排除在外。第 II 组和第 III 组患者均为 II 期 A 级牙周炎。参与者被分为三组：第 I 组为阴性对照组（牙龈健康个体），第 II 组（SRP）接受 SRP 治疗，第 III 组（姜黄素凝胶）在 SRP 后每周应用四次，共四周。在基线和六周后收集临床指标（菌斑指数（PI）、牙龈指数（GI）、临床附着水平（CAL）和探诊深度（PD））和使用酶联免疫吸附试验（ELISA）检测唾液降钙素原（PCT）水平。
这项在 ClinicalTrials.gov 上注册的随机对照临床试验（NCT05667376）于 2022 年 12 月 28 日首次发布，共纳入 54 名患者（20 名男性；34 名女性）。关于年龄和性别分布，三组之间没有统计学上的显著差异（p>0.05）。在基线时，第 II 组和第 III 组之间的 PI、GI、PPD 和 CAL 无统计学差异（p>0.05）。然而，与第 I 组相比，第 II 组和第 III 组的临床参数在基线时均有统计学差异（p≤0.05）。治疗六周后，第 III 组的 PI、PD 和 CAL 改善程度大于第 II 组（p≤0.05）。关于 PCT 值，在基线时，第 II 组和第 III 组之间没有统计学差异（p>0.05）。然而，第 II 组、第 III 组和第 I 组之间有统计学差异（p≤0.05）。治疗六周后，第 II 组和第 III 组的 PCT 水平均有统计学下降（p≤0.05）。
与 SRP 相比，姜黄素凝胶的应用对所有临床指标均有显著影响。
