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老年人失眠:综述。

Insomnia in the Elderly: A Review.

机构信息

Department of Geriatrics, Wayne State University School of Medicine, Detroit, Michigan.

出版信息

J Clin Sleep Med. 2018 Jun 15;14(6):1017-1024. doi: 10.5664/jcsm.7172.

DOI:10.5664/jcsm.7172
PMID:29852897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5991956/
Abstract

BACKGROUND

Insomnia remains one of the most common sleep disorders encountered in the geriatric clinic population, frequently characterized by the subjective complaint of difficulty falling or maintaining sleep, or nonrestorative sleep, producing significant daytime symptoms including difficulty concentrating and mood disturbances.

METHODS

A search of the literature was conducted to review the epidemiology, definition, and age-related changes in sleep, as well as factors contributing to late-life insomnia and scales utilized for the assessment of insomnia in older people. The aim is to summarize recent diagnostic guidelines and both nonpharmacological and pharmacological strategies for the management of insomnia in the older population.

RESULTS

Insomnia remains a clinical diagnosis. There are several demographic, psychosocial, biologic, and behavioral factors that can contribute to late-life insomnia. Older adults are at higher risk for the medical and psychiatric effects of insomnia.

CONCLUSIONS

The most important aspect in evaluation of insomnia is detailed history taking and thorough physical examination. Nonpharmacological treatment options have favorable and enduring benefits compared to pharmacological therapy.

摘要

背景

失眠仍然是老年诊所人群中最常见的睡眠障碍之一,其特征通常是主观抱怨入睡困难或难以维持睡眠,或睡眠质量差,导致白天出现明显的症状,包括注意力不集中和情绪紊乱。

方法

对文献进行了检索,以综述流行病学、定义以及与年龄相关的睡眠变化,以及导致老年人失眠的因素和用于评估老年人失眠的量表。目的是总结老年人失眠的最新诊断指南以及非药物和药物治疗策略。

结果

失眠仍然是一种临床诊断。有几个人口统计学、心理社会、生物和行为因素可能导致老年人失眠。老年人更容易受到失眠的医学和精神影响。

结论

评估失眠的最重要方面是详细的病史采集和全面的体格检查。与药物治疗相比,非药物治疗方案具有更好的和持久的益处。

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本文引用的文献

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Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline.《成人慢性失眠症药物治疗临床实践指南:美国睡眠医学会临床实践指南》
J Clin Sleep Med. 2017 Feb 15;13(2):307-349. doi: 10.5664/jcsm.6470.
2
Novel class of medications, orexin receptor antagonists, in the treatment of insomnia - critical appraisal of suvorexant.新型药物类别——食欲素受体拮抗剂治疗失眠症——对苏沃雷生的批判性评价
Nat Sci Sleep. 2016 Jul 14;8:239-47. doi: 10.2147/NSS.S76910. eCollection 2016.
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Management of Chronic Insomnia Disorder in Adults: A Clinical Practice Guideline From the American College of Physicians.成人慢性失眠症管理:美国医师学院临床实践指南。
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Suvorexant in insomnia: efficacy, safety and place in therapy.苏沃雷生治疗失眠:疗效、安全性及在治疗中的地位。
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American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults.美国老年医学会2015年更新的《老年人潜在不适当用药的Beers标准》
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Connections between sleep and cognition in older adults.老年人睡眠与认知的关系。
Lancet Neurol. 2014 Oct;13(10):1017-28. doi: 10.1016/S1474-4422(14)70172-3.
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Poor sleep quality is associated with increased cortical atrophy in community-dwelling adults.睡眠质量差与社区居住成年人的皮质萎缩增加有关。
Neurology. 2014 Sep 9;83(11):967-73. doi: 10.1212/WNL.0000000000000774. Epub 2014 Sep 3.
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Hippocampal substructural vulnerability to sleep disturbance and cognitive impairment in patients with chronic primary insomnia: magnetic resonance imaging morphometry.慢性原发性失眠患者海马亚结构对睡眠障碍和认知损害的易损性:磁共振成像形态学
Sleep. 2014 Jul 1;37(7):1189-98. doi: 10.5665/sleep.3836.
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Residual effects of zopiclone 7.5 mg on highway driving performance in insomnia patients and healthy controls: a placebo controlled crossover study.7.5毫克佐匹克隆对失眠患者和健康对照者高速公路驾驶性能的残留影响:一项安慰剂对照交叉研究。
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